β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Mapping the Supratentorial Cerebral Arterial Territories Using 1160 Large Artery Infarcts
JAMA Neurology, 2019 Importance Cerebral vascular territories are of key clinical importance in patients with stroke, but available maps are highly variable and based on prior studies with small sample sizes.
Dong-Eog Kim +31 more
semanticscholar +1 more source
Importance of transport security in the realization of Russia’s national interests
Путеводитель предпринимателя, 2020 Only the presence and intensive development of the transport infrastructure in the Russian Federation, including all existing modes of transport, including road, rail, air, inland water, sea, other modes of transport, can ensure the sustainable ...
A. M. Novozhilov
doaj
The ecology of the kākerōri (Rarotonga flycatcher) Pomarea dimidiata, with special reference to fledged young : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Ecology at Massey University [PDF]
, 1993 The Kakerori (Pomarea dimidiata) is a small flycatcher, endemic to Rarotonga in the Cook Islands. In August 1991 the total world population was estimated at 47 individuals, an increase of 14 birds from the previous year.
Sanders, Kerry H.
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Chromosome territories and the global regulation of the genome
Genes, Chromosomes and Cancer, 2019 Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically associating domains (TADs) to higher level compartments culminating in ...
A. Fritz +4 more
semanticscholar +1 more source
SUSTAINABLE DEVELOPMENT OF TERRITORIES OF MINING REGIONS [PDF]
, 2018 Developing innovative technologies of mining coal seams and increasing the competitiveness of coal produced and providing further diversification of the mine using the "post-mining" concept as the basis for sustainable ...
DUBOVIK, Oleksandr, LOHUNOVA, Oleksandra
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Recording, Documentation, and Information Management for the Conservation of Heritage Places: Guiding Principles [PDF]
, 2008 Provides guidance on integrating recording, documentation, and information management of territories, sites, groups of buildings, or monuments into the conservation process; evaluating proposals; consulting specialists; and controlling ...
Francois LeBlanc +2 more
core
A different appetite for sovereignty? Independence movements in subnational island jurisdictions [PDF]
, 2012 Local autonomy in a subnational jurisdiction is more likely to be gained, secured or enhanced where there are palpable movements or political parties agitating for independence in these smaller territories.
Anckar D. +27 more
core +2 more sources