Results 131 to 140 of about 1,455,714 (333)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

On the presence of sustainable growth trends in the research sector in the RF territories

open access: yesВестник Северо-Кавказского федерального университета
Introduction. The work analyzes regional statistics on labor productivity and cost efficiency in the Russian research sector. It also examines international experience in disseminating the knowledge economy.Goal. The paper identifies the stability of the
D. Yu. Fraimovich   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

The deterritorialization of rural schools in southern Brazil: conflicts, resistances, and challenges

open access: yesRevista Brasileira de Educação do Campo
This study investigates the processes of rural school closures in Southern Brazil, contextualizing them within the transformations of the Brazilian rural space.
Cassia Betania Rodrigues Santos
doaj   +1 more source

One in Christ [PDF]

open access: yes, 2006
Historical series, 8. Sermon delivered to the congregations of the Synod of Alberta and the Territories of the Evangelical Lutheran Church in Canada, 21 Je 1998.
Kristenson, Stephen P.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

From territorial diagnosis to strategic intent. Knowledge brokerage and co-construction. Fieldwork Insights from Karst Landscapes – the poljes of Canton 10 (Bosnia and Herzegovina)

open access: yesVertigO
This article defends the idea that with a territorial diagnosis, using an inductive and comprehensive approach, it is possible to develop an integrated and systemic approach, and to extract themselves from the thematic logics that constrain environmental
Orianne Crouteix   +2 more
doaj   +1 more source

The Role of Exclusive Territories in Producers' Competition [PDF]

open access: yes
The central objective of this paper is to show how vertical restraints, which affect intra-brand competition, can and will be used as an effective mechanism for reducing inter-brand competition and increasing producer profits.
Joseph Stiglitz, Patrick Rey
core  

Yahoo and Democracy on the Internet [PDF]

open access: yes, 2001
This article examines the French court order requiring Yahoo to prevent French Internet users from accessing images of Nazi memorabilia available for auction on the company\u27s American web site.
Reidenberg, Joel R.
core   +1 more source

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