Results 61 to 70 of about 2,094,634 (340)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Indiana Territory and Early Statehood, 1800-1825 [PDF]

, 1987
This handbook was developed to encourage more effective state citizenship through the teaching of state history. Attention is given to geographical factors, politics, government, social and economic changes, and cultural ...
Geib, George W.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Running into New Territory in SUSY Parameter Space

, 2004
The LEP-II bound on the light Higgs mass rules out the vast majority of parameter space left to the Minimal Supersymmetric Standard Model (MSSM) with weak-scale soft-masses.
A. Bartl, A. Finch, A.C. Bawa, Antonio Delgado, D. Cavalli ., D.E. Kaplan, David E Kaplan, E.L. Berger, E.L. Berger, G.D. Kribs, H.E. Haber, H.E. Haber, H.J. He, Higgs Working Group collaboration, J.A. Casas, J.F. Gunion, J.L. Hewett, J.R. Ellis, K.S. Babu, LEP Higgs Working group, LEP Higgs Working Group collaboration, M. Beneke ., M. Cvetic, M. Drees, P. Batra, Puneet Batra, Q.H. Cao, R. Harnik, R.S. Chivukula, S.P. Martin, Tim M.P Tait, U. Ellwanger, Y. Okada, Z. Chacko, Z. Sullivan   +34 more
core   +2 more sources

Metabarcoding of the Soil Fungal Microbiome and Its Environmental Drivers Across Temporal and Spatial Scales

Environmental DNA
Understanding microbial community composition and the factors influencing it is essential for effective ecological surveillance and biomonitoring. Advancements in non‐invasive sampling and metabarcoding have improved the understanding of soil fungal ...
Elnaz Saki, Sonu Yadav
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Controlling Patent Prosecution History [PDF]

, 2010
[Excerpt] “One of the most salient effects of patent prosecution history arises in the context of the doctrine of equivalents. Under that doctrine, although patent claims may be found to be broader than their literal scope, territory surrendered during ...
Field, Thomas G., Jr.
core   +1 more source

Charting Unexplored Dwarf Galaxy Territory With RR Lyrae

, 2015
Observational bias against finding Milky Way (MW) dwarf galaxies at low Galactic latitudes (b < 20 deg) and at low surface brightnesses (fainter than 29 mag arcsec^-2, in the V-band) currently limits our understanding of the faintest limits of the galaxy
Baker, Mariah, Willman, Beth
core   +1 more source

Evaluating a novel model of hepatitis B care, Hep B PAST, in the Northern Territory of Australia: results from a prospective, population-based studyResearch in context

The Lancet Regional Health. Western Pacific
Summary: Background: The Northern Territory (NT) has the highest prevalence of chronic hepatitis B (CHB) in Australia. The Hep B PAST program aims to improve health outcomes for people living with CHB.
Kelly Hosking, Paula Binks, Teresa De Santis, Phillip Merrdi Wilson, George Garambaka Gurruwiwi, Sarah Mariyalawuy Bukulatjpi, Emily Vintour-Cesar, Melita McKinnon, Peter Nihill, Tammy-Allyn Fernandes, Belinda Greenwood-Smith, Robert Batey, Cheryl Ross, Steven Y.C. Tong, Geoffrey Stewart, Catherine Marshall, Catherine Gargan, Prashanti Manchikanti, Karen Fuller, Jaclyn Tate-Baker, Sami Stewart, Benjamin Cowie, Nicole Allard, Jennifer H. MacLachlan, Ashleigh Qama, David Boettiger, Joshua S. Davis, Christine Connors, Jane Davies   +28 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source