Results 151 to 160 of about 798,978 (348)

Thermodynamic and structural studies on the human serum albumin in the presence of a polyoxometalate [PDF]

The interaction of a polyoxometal (POM), K₆SiW ₁₁Co(H₂O)O₃₉.10H₂O (K₆) as a Keggin, with human serum albumin (HSA ...
امانی, مجتبی, بهنام, حسین, حسنی, زهرا, رنجبر, بیژن, صبوری, علی اکبر, عاجلو, داوود, علیزاده, کمال, قرنفولی, محسن, محمدی زنوزی, فرخزاد, موسوی موحدی, علی اکبر   +9 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Prediction of Protein Function from Tertiary Structure of the Active Site in Heme Proteins by Convolutional Neural Network. [PDF]

Biomolecules, 2023
Kondo HX, Iizuka H, Masumoto G, Kabaya Y, Kanematsu Y, Takano Y.   +5 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression. [PDF]

Sci Rep, 2022
Zahra K, Shabbir M, Badshah Y, Trembley JH, Badar Z, Khan K, Afsar T, Almajwal A, Alruwaili NW, Razak S.   +9 more
europepmc   +1 more source

Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers

FEBS Open Bio, EarlyView.
Microbial biosynthesis and engineered enzyme platforms are expanding the design space of polyhydroxyalkanoate bioplastics. By combining fermentation, PHA synthase engineering and cell‐free modular systems, tailored biodegradable polymers can be produced with tunable properties, supporting more sustainable materials and future circular bioeconomy ...
Giovanni Gallo, Emma Piccoli, Luca Bombardi, Martina Aulitto, Salvatore Fusco   +4 more
wiley   +1 more source

T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle

EBioMedicine
Summary: Immune therapies represented by immune checkpoint blockade (ICB) have significantly transformed cancer treatment. However, the effectiveness of these treatments depends on the status of T cells.
Wen-Ping Lin, Hao Li, Zhi-Jun Sun
doaj   +1 more source

RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics. [PDF]

Nucleic Acids Res, 2022
Biedenbänder T, de Jesus V, Schmidt-Dengler M, Helm M, Corzilius B, Fürtig B.   +5 more
europepmc   +1 more source

ToGo-WF: prediction of RNA tertiary structures and RNA–RNA/protein interactions using the KNIME workflow [PDF]

, 2019
Satoshi Yamasaki, Takayuki Amemiya, Yukimitsu Yabuki, Katsuhisa Horimoto, Kazuhiko Fukui   +4 more
openalex   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source