Results 131 to 140 of about 798,877 (294)

Prediction of Protein Function from Tertiary Structure of the Active Site in Heme Proteins by Convolutional Neural Network. [PDF]

Biomolecules, 2023
Kondo HX, Iizuka H, Masumoto G, Kabaya Y, Kanematsu Y, Takano Y.   +5 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression. [PDF]

Sci Rep, 2022
Zahra K, Shabbir M, Badshah Y, Trembley JH, Badar Z, Khan K, Afsar T, Almajwal A, Alruwaili NW, Razak S.   +9 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle

EBioMedicine
Summary: Immune therapies represented by immune checkpoint blockade (ICB) have significantly transformed cancer treatment. However, the effectiveness of these treatments depends on the status of T cells.
Wen-Ping Lin, Hao Li, Zhi-Jun Sun
doaj   +1 more source

RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics. [PDF]

Nucleic Acids Res, 2022
Biedenbänder T, de Jesus V, Schmidt-Dengler M, Helm M, Corzilius B, Fürtig B.   +5 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Prediction of the RNA Tertiary Structure Based on a Random Sampling Strategy and Parallel Mechanism. [PDF]

Front Genet, 2021
Liu Z, Yang Y, Li D, Lv X, Chen X, Dai Q.   +5 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Design and Synthesis of Crosslinked Helix Dimers as Protein Tertiary Structure Mimics. [PDF]

Curr Protoc, 2022
Hong SH, Nguyen T, Arora P.
europepmc   +1 more source