Results 151 to 160 of about 291,656 (309)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression. [PDF]

Sci Rep, 2022
Zahra K, Shabbir M, Badshah Y, Trembley JH, Badar Z, Khan K, Afsar T, Almajwal A, Alruwaili NW, Razak S.   +9 more
europepmc   +1 more source

Ipsative assessment within an integrated assessment structure – a case study in the Graduate Certificate in the Practice of Tertiary Teaching

, 2005
The University of Newcastle is the largest regional University in Australia with a student population of 25,000 and academic staff of 650. In 2004 the University responded to the lack of response to an existing Graduate Certificate in Tertiary Teaching ...
Alderman, Lyn
core  

Probing the Structure of an RNA Tertiary Unfolding Transition State

, 2016
Probing the Structure of an RNA Tertiary Unfolding Transition ...
Emily J. Maglott (3007479), Gary D. Glick (351616), Jay T. Goodwin (2701942)   +2 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle

EBioMedicine
Summary: Immune therapies represented by immune checkpoint blockade (ICB) have significantly transformed cancer treatment. However, the effectiveness of these treatments depends on the status of T cells.
Wen-Ping Lin, Hao Li, Zhi-Jun Sun
doaj   +1 more source

RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics. [PDF]

Nucleic Acids Res, 2022
Biedenbänder T, de Jesus V, Schmidt-Dengler M, Helm M, Corzilius B, Fürtig B.   +5 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Prediction of the RNA Tertiary Structure Based on a Random Sampling Strategy and Parallel Mechanism. [PDF]

Front Genet, 2021
Liu Z, Yang Y, Li D, Lv X, Chen X, Dai Q.   +5 more
europepmc   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source