Results 121 to 130 of about 291,656 (309)

Accurate and Automated Classification of

, 2003
PsiCSI is a highly accurate and automated method of assigning secondary structure from NMR data, which is a useful intermediate step in the determination of tertiary structures.
Protein Secondary Structure
core  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Alignment analysis of TMPRSS2 protein tertiary structure.

Alignment analysis of TMPRSS2 protein tertiary structure.
Marzieh Eskandarzadeh (18388767), Ali Mohebbi (4433587), Hanieh Zangi (18388770), Marzie Fatehi (18388773)   +3 more
core   +1 more source

Structure and alpine evolution of the Madrid basin

, 1995
The Madrid basin is intracratonic and triangular in form, being bounded on its three sides by Tertiary mountain ranges: the Spanish Central System in the north, the Toledo mountains in the south, and the Iberian and Altomira ranges in the east.
González-Casado, J.M., Vicente Muñoz, Gerardo De, Rodríguez Pascua, Miguel Angel, Muñoz Martín, Alfonso, Giner Robles, Jorge Luis   +4 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

RNA Tertiary Structure Analysis by 2′-Hydroxyl Molecular Interference

, 2014
We introduce a melded chemical and computational approach for probing and modeling higher-order intramolecular tertiary interactions in RNA. 2'-Hydroxyl molecular interference (HMX) identifies nucleotides in highly packed regions of an RNA by exploiting ...
Tandon, Arpit, Weeks, Kevin M., Greggory M. Rice, Philip J. Homan, Feng Ding, Dokholyan, Nikolay V., Kevin M. Weeks, Homan, Philip J., Ding, Feng, Nikolay V. Dokholyan, Arpit Tandon, Rice, Greggory M.   +11 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

RNA Tertiary Structure Analysis by 2′-Hydroxyl Molecular Interference

, 2016
: We introduce a melded chemical and computational approach for probing and modeling higher-order intramolecular tertiary interactions in RNA. 2′-Hydroxyl molecular interference (HMX) identifies nucleotides in highly packed regions of an RNA by ...
Greggory M. Rice, Philip J. Homan, Arpit T, Feng Ding, Arpit Tandon (476362), Nikolay V. Dokholyan (84409), Kevin M. Weeks (367405), Kevin M. Weeks, Greggory M. Rice (1727200), Nikolay V. Dokholyan, Philip J. Homan (1727203), Feng Ding (33360)   +11 more
core   +1 more source