Results 101 to 110 of about 291,656 (309)

A further leap of improvement in tertiary structure prediction in CASP13 prompts new routes for future assessments

We present our assessment of tertiary structure predictions for hard targets in Critical Assessment of Structure Prediction round 13 (CASP13). The analysis includes (a) assignment and discussion of best models through scores-aided visual inspection of ...
Dal Peraro, Matteo, Tamo, Giorgio E., Abriata, Luciano A.   +2 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain

, 2010
Long-range tertiary interactions determine the three-dimensional structure of a number of metabolite-binding riboswitch RNA elements and were found to be important for their regulatory function. For the guanine-sensing riboswitch of the Bacillus subtilis
Wöhnert, Jens, Buck, Janina, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +3 more
core   +1 more source

Validation score of OsAPY tertiary structure via different tools.

, 2023
Validation score of OsAPY tertiary structure via different tools.
Md. Ashrafuzzaman (15447642), Md. Qamrul Islam (11610700), Nurnabi Azad Jewel (11610703), Shamsul H. Prodhan (9099090), Md. Mashiur Rahaman (10269888), Hammadul Hoque (10269894), Md. Rakib Wazed Nayon (15447639), Aniqua Tasnim Chowdhury (15447633), Fahmid H. Bhuiyan (15447636), Md. Nazmul Hasan (11525006)   +9 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Advances in protein tertiary structure prediction

Biomedical and Biotechnology Research Journal, 2018
Proteins are composed of linear chains of amino acids that form a unique three-dimensional structure in their native environment. Such native structure favors the proteins to perform their biochemical activity.
Tayebeh Farhadi
doaj   +1 more source

Poster 4: Tertiary Structure

, 2015
When proteins form polypeptide chains, they form primary structure - their amino acid sequence - secondary structure - their local shapes - and tertiary structure - their global fold and shape.
Adams, Andrew, \u2716, Carlberg, Grace, \u2716, Xu, Andy, \u2716   +2 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A Review of Deep Generative Models for Distance Matrices in Protein Structure Modeling [PDF]

IJCI International Journal of Computers and Information
Deep generative models are being explored as a promising approach for generating distance matrix representations of protein tertiary structures. These models capture the complex spatial arrangement of amino acid residues, but challenges remain in ...
Aalaa Sehsah, Afaf Mousa, Gamal Elhady
doaj   +1 more source

School-leavers' Transition to Tertiary Study: a Literature Review. [PDF]

The theoretical and empirical literature relating to factors and problems in the transition of students from secondary to tertiary level education is reviewed here.
Evans, M.
core