Results 101 to 110 of about 7,456,122 (302)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Batchelor Institute of Indigenous Tertiary Education annual report 2013
, 2013 Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT)
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Batchelor Institute of Indigenous Tertiary Education annual report 2010
, 2010 Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT)
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Batchelor Institute of Indigenous Tertiary Education annual report 2000
, 2000 Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT)
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Batchelor Institute of Indigenous Tertiary Education annual report 2006
, 2006 Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT)
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The tertiary structure of BmTHY.
, 2013 (a)The tertiary structure of BmTHY(strands); (b)The tertiary structure of BmTHY(Molecular Surface).
Dailing Fang (331673) +9 more
core +1 more source