Results 21 to 30 of about 12,337 (202)

Integrating machine learning and single-cell trajectories to analyze T-cell exhaustion to predict prognosis and immunotherapy in colon cancer patients

open access: yesFrontiers in Immunology, 2023
IntroductionThe incidence of colon adenocarcinoma (COAD) has recently increased, and patients with advanced COAD have a poor prognosis due to treatment resistance.
Xiaogang Shen   +9 more
doaj   +1 more source

Glycosylated haemoglobin (A1c) best values for type 2 diabetes in the battlefield much ado about nothing? (apparently) [PDF]

open access: yes, 2019
Despite intensive research, therapy of diabetes mellitus type 2 (T2DM) is far from be effective. The most important unresolved issue is to establish a safe glycosylated hemoglobin C (A1c) value well balanced between benefit and side effects.
Adami, Giovanni   +3 more
core   +1 more source

Extensive osteonecrosis of the maxilla caused by bisphosphonates : report of a rare case [PDF]

open access: yes, 2019
Bisphosphonates are drugs indicated for the treatment of bone metabolic diseases or malignant hypercalcemia. They are generally well-tolerated drugs, however, recent reports have described osteonecrosis of the jaw bones as a potentially serious ...
Costa, Davi   +4 more
core   +1 more source

Self-care coping strategies in people with diabetes: a qualitative exploratory study [PDF]

open access: yes, 2009
Background The management of diabetes self-care is largely the responsibility of the patient. With more emphasis on the prevention of complications, adherence to diabetes self-care regimens can be difficult.
Collins, Margaret M   +3 more
core   +8 more sources

Musculo-cutaneous flap for reconstruction surgery for deep surgical site infection after total en bloc spondylectomy: A technical note

open access: yesInterdisciplinary Neurosurgery, 2018
Background: Total en bloc spondylectomy (TES) is potential radical resection surgery for spinal tumors. Surgical procedure of TES includes extremely wide detachment of surrounding soft tissue from pathological vertebra, resulting in impairment of blood ...
Masao Koda, MD, PhD   +5 more
doaj   +1 more source

Transdermal Spray in Hormone Delivery [PDF]

open access: yes, 2014
This review examines advances in hormone delivery, particularly using transdermal spray. Transdermal gels, emulsions, patches, subcutaneous implants and sprays have been developed for transdermal hormone therapy in recent years.
Algin-Yapar, E, Inal, Ö
core   +2 more sources

Safety Assessment of Glucose-Lowering Drugs and Importance of Structured Education during Ramadan : A Systematic Review and Meta-Analysis [PDF]

open access: yes, 2022
Background. Ramadan is the sacred month of the Islamic Hijri (lunar) calendar, and during this entire month, healthy adult Muslims abstain from eating and drinking from dawn to sunset.
Akhil, Ayesha   +5 more
core   +1 more source

Feedback on the FDA's February 2006 draft guidance on Patient Reported Outcome (PRO) measures from a developer of PRO measures [PDF]

open access: yes, 2006
I believe that the FDA guidelines have already had an impact in encouraging good practice in the use of PROs. There are, however, important improvements that need to be made to the guidelines, particularly in the use of health status and quality of life ...
Bradley, Clare
core   +7 more sources

Recurrent giant cell tumour of the thoracic spine managed by total en bloc spondylectomy and denosumab therapy: a case report

open access: yesBMC Musculoskeletal Disorders, 2020
Background Giant cell tumour (GCT) of the bone is a rare, invasive benign bone tumour, which typically originates in the metaphyseal ends of long bones and rarely in the spine.
Ping-Guo Duan   +4 more
doaj   +1 more source

Identifying routine clinical predictors of non-adherence to second line therapies in Type 2 diabetes: a retrospective cohort analysis in a large primary care database [PDF]

open access: yes, 2019
This is the final version. Available on open access from Wiley via the DOI in this recordData available: The data were used under a licence from CPRD. CPRD data can be obtained through submission to CPRD’s Independent Scientific Advisory CommitteeAims:
Farmer, AJ, Hattersley, A, Shields, B
core   +2 more sources

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