Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.As a local breed adapted to the extreme environment of the Tibetan Plateau, Tibetan pigs have not yet been systematically characterized in terms of their gut viral communities. In this study, we applied viral metagenomics to sequence fecal samples from 191 Tibetan pigs (including both healthy and diarrheal individuals) across four farms in Nyingchi ...
Jiaheng Chen +11 more
wiley +1 more source
In vivo measurement of afferent activity with axon-specific calcium imaging. [PDF]
, 2018 In vivo calcium imaging from axons provides direct interrogation of afferent neural activity, informing the neural representations that a local circuit receives.
Broussard, Gerard Joey +8 more
core
, 2019 Influenza A virus (IAV) infection poses a serious health threat and novel antiviral strategies are needed. Defective interfering particles (DIPs) can be generated in IAV infected cells due to errors of the viral polymerase and may suppress spread of wild
Arora, P. +6 more
core +2 more sources
PAX6 isoforms, along with reprogramming factors, differentially regulate the induction of cornea-specific genes [PDF]
, 2016 PAX6 is the key transcription factor involved in eye development in humans, but the differential functions of the two PAX6 isoforms, isoform-a and isoform-b, are largely unknown.
Hayashi, Ryuhei +9 more
core +2 more sources
Blastocyst complementation generates exogenous donor‐derived liver in ahepatic pigs
The FASEB Journal, Volume 38, Issue 21, 15 November 2024.We report for the first time the generation of gut‐specific knockout of HHEX required for hepatogenesis and rescued the mutants by chimerism. Key highlights are below: Generated a gut‐specific CRE driver in a pig model. Generated and characterized the conditional knockout of HHEX required for hepatogenesis.
Sean G. Simpson +7 more
wiley +1 more source
Risk analysis tool developed to assist with decision-making on prevention of swine diseases. Application to Porcine Epidemic Diarrhea in Caribbean countries. [P029] [PDF]
, 2015 Purpose Classical Swine Fever (CSF) and Teschovirus Encephalomyelitis (TE) have been identified as priority diseases for the Caribbean because of their sanitary, economic and social repercussions in affected countries, together with their high diffusion ...
Calvo, Francisco +9 more
core
Lentiviral vectors can be used for full-length dystrophin gene therapy [PDF]
, 2017 Duchenne Muscular Dystrophy (DMD) is caused by a lack of dystrophin expression in patient muscle fibres. Current DMD gene therapy strategies rely on the expression of internally deleted forms of dystrophin, missing important functional domains.
Asgarian, Z +10 more
core +2 more sources
Enterovirusten tyypitys RT-qPCR-menetelmällä [PDF]
, 1999 Työn tarkoituksena oli optimoida toimiva ja herkkä RT-qPCR-menetelmä enterovirusten tyypittämiseksi monistamalla enterovirusgenomin VP1-aluetta. Optimoinnissa käytettiin näytteinä plasmidiin kloonattuja virusgenomeja ja virus-RNA:ta, jotka oli eristetty ...
Jaume Llistosella i Vidal +2 more
core +1 more source
Epidemiologic investigation of immune-mediated polyradiculoneuropathy among abattoir workers exposed to porcine brain [PDF]
, 2003 Background In October 2007, a cluster of patients experiencing a novel polyradiculoneuropathy was identified at a pork abattoir (Plant A). Patients worked in the primary carcass processing area (warm room); the majority processed severed heads (head ...
Holzbauer, Stacy M. +21 more
core +2 more sources
Multiple Sclerosis Gene Therapy Using Recombinant Viral Vectors: Overexpression of IL-4, IL-10 and Leukemia Inhibitory Factor in Wharton's Jelly Stem Cells in The EAE Mice Model [PDF]
, 2017 Objective: Immunotherapy and gene therapy play important roles in modern medicine. The aim of this study is to evaluate the overexpression of interleukin-4 (IL-4), IL-10 and leukemia inhibitory factor (LIF) in Wharton's jelly stem cells (WJSCs) in the ...
Abdolhosseinzadeh, Baharak. +7 more
core +1 more source