Results 81 to 90 of about 2,910 (186)

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, Volume 5, Issue 4, August 2025.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

No evidence of enteric viral involvement in the new neonatal porcine diarrhoea syndrome in Danish pigs

BMC Veterinary Research, 2017
Background The aim of this study was to investigate whether the syndrome New Neonatal Porcine Diarrhoea Syndrome (NNPDS) is associated with a viral aetiology.
N. B. Goecke, C. K. Hjulsager, H. Kongsted, M. Boye, S. Rasmussen, F. Granberg, T. K. Fischer, S. E. Midgley, L. D. Rasmussen, Ø. Angen, J. P. Nielsen, S. E. Jorsal, L. E. Larsen   +12 more
doaj   +1 more source

Endocytic turnover of Rab8 controls cell polarization [PDF]

, 2017
Adaptation of cell shape and polarization through the formation and retraction of cellular protrusions requires balancing of endocytosis and exocytosis combined with fine-tuning of the local activity of small GTPases like Rab8.
Francis, Monika K., Hachimi, Mariam, Holst, Mikkel R., Larsson, Elin, Lundmark, Richard, Martin-Belmonte, Fernando, Peranen, Johan, Vidal-Quadras, Maite, Yau, Wai-Lok   +8 more
core   +1 more source

A game of tag: A review of protein tags for the successful detection, purification and fluorescence labelling of proteins expressed in microalgae

The Plant Journal, Volume 122, Issue 6, June 2025.
Significance Statement Protein tags for detection, purification and fluorescence labelling are vital in microalgal research, yet the suitability of specific tags remains largely unexplored. This review discusses the pros and cons of a comprehensive list of protein tags and provides important guidance for experimental design within a microalgal context.
Jonathan Scarfe, Darius Kosmützky, R. Ellen R. Nisbet   +2 more
wiley   +1 more source

Neuropeptide VF neurons promote sleep via the serotonergic raphe [PDF]

, 2020
Although several sleep-regulating neuronal populations have been identified, little is known about how they interact with each other to control sleep/wake states.
Andreev, Andrey, Cammidge, Tasha, Hong, Young, Hurley, Hannah, Lee, Daniel A., Oikonomou, Grigorios, Prober, David A.   +6 more
core  

Unique Characteristics of a Picornavirus Internal Ribosome Entry Site from the Porcine Teschovirus-1 Talfan [PDF]

Journal of Virology, 2002
ABSTRACT The teschoviruses constitute a recently defined picornavirus genus. Most of the genome sequence of the porcine teschovirus-1 (PTV) Talfan and several other strains is known. We now demonstrate that initiation of protein synthesis occurs at nucleotide (nt) 412 on the PTV Talfan RNA and that nt 1 to 405 contains an internal ribosome ...
Kaku, Yoshihiro, Chard, Louisa S., Inoue, Toru, Belsham, Graham J.   +3 more
openaire   +3 more sources

Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer

Advanced Science, Volume 12, Issue 18, May 15, 2025.
This study provides proof‐of‐concept evidence showing that through direct killing, antigen presentation, and competitively binding to BTN3A1, Vγ9Vδ2 T cells amplified from cervical cancer (CC) patients can synergize with αβ T cells to exert anti‐CC function both in vitro and in vivo.
Min Wu, Jian Liu, Liting Liu, Yifan Yang, Hong Liu, Long Yu, Haihong Zeng, Shuo Yuan, Ruiyi Xu, Hangyu Liu, Han Jiang, Shen Qu, Liming Wang, Ying Chen, Jingyu Wang, Yuwei Zhang, Shan He, Ling Feng, Junyan Han, Wanjiang Zeng, Hui Wang, Yafei Huang   +21 more
wiley   +1 more source

Molecular survey of porcine teschovirus, porcine sapelovirus, and enterovirus G in captive wild boars (Sus scrofa scrofa) of Paraná state, Brazil

Pesquisa Veterinária Brasileira, 2015
Porcine teschovirus (PTV), porcine sapelovirus (PSV), and enterovirus G (EV-G) are infectious agents specific to pig host species that are endemically spread worldwide.
Daiane G. Donin, Raquel de A. Leme, Alice F. Alfieri, Geraldo C. Alberton, Amauri A. Alfieri   +4 more
doaj   +1 more source

Steric regulation of tandem calponin homology domain actin-binding affinity. [PDF]

, 2019
Tandem calponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and organize the actin cytoskeleton. Despite regions of high sequence similarity, CH1-CH2 domains can have remarkably different actin-binding ...
Bausch, Andreas, Belardi, Brian, Fletcher, Daniel A, Harris, Andrew R, Jreij, Pamela, Shams, Hengameh, Wei, Kathy   +6 more
core   +1 more source

Sapovirus translation requires an interaction between VPg and the cap binding protein eIF4E. [PDF]

, 2014
UNLABELLED: Sapoviruses of the Caliciviridae family of small RNA viruses are emerging pathogens that cause gastroenteritis in humans and animals. Molecular studies on human sapovirus have been hampered due to the lack of a cell culture system.
Chaudhry, Yasmin, Cho, Kyoung-Oh, Goodfellow, Ian, Hosmillo, Myra, Kim, Deok-Song   +4 more
core   +2 more sources