Results 91 to 100 of about 2,910 (186)

Longitudinal Investigation of Brain and Spinal Cord Pericytes After Inducible PDGFRβ+ Cell Ablation in Adult Mice

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
Pericytes are essential for central nervous system vascular function, yet studying their role in adult pathologies has been challenging due to the scarcity of well‐characterized models that preserve normal vascular development. A tamoxifen‐inducible pericyte ablation model was developed to investigate pericyte dynamics after the acute loss of pericytes.
Dila Atak, Erdost Yıldız, Esra Özkan, Mohammadreza Yousefi, Ayşe Özkan, Aysu Bilge Yılmaz, Ali Burak Kızılırmak, Iman Asaad Alnajjar, Çiçek Kanar, Zeynep Lal Caan, Şakir Ümit Zeybek, Cem İsmail Küçükali, Erdem Tüzün, Yasemin Gürsoy‐Özdemir, Atay Vural   +14 more
wiley   +1 more source

Biomimetic Triplet Messenger RNA Formulation in MXene Hydrogel Microneedles for Wound Healing

Aggregate, Volume 6, Issue 2, February 2025.
The current direction in the messenger RNA (mRNA) field is focused on imparting mRNA with competitive synthetic functions and delicating carrier systems. By leveraging advanced artificial intelligence technology, a novel triplet mRNA formulation has been developed and delivered via photothermal‐responsive microneedles for the treatment of diabetic ...
Ji Wang, Yu Wang, Minhui Lu, Xinyue Cao, Ming Xia, Miaoqing Zhao, Yuanjin Zhao   +6 more
wiley   +1 more source

Lentiviral vectors can be used for full-length dystrophin gene therapy [PDF]

, 2017
Duchenne Muscular Dystrophy (DMD) is caused by a lack of dystrophin expression in patient muscle fibres. Current DMD gene therapy strategies rely on the expression of internally deleted forms of dystrophin, missing important functional domains.
Asgarian, Z, Counsell, JR, Danos, O, Ferrer, V, Howe, SJ, Meng, J, Morgan, JE, Muntoni, F, Thrasher, AJ, Vink, CA, Waddington, SN   +10 more
core   +2 more sources

Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus

mLife, Volume 4, Issue 1, Page 55-69, February 2025.
Abstract The global dissemination of H5 avian influenza viruses represents a significant threat to both human and animal health. In this study, we conducted a genome‐wide siRNA library screening against the highly pathogenic H5N1 influenza virus, leading us to the identification of 457 cellular cofactors (441 proviral factors and 16 antiviral factors ...
Guangwen Wang, Li Jiang, Jinliang Wang, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li   +15 more
wiley   +1 more source

PAX6 isoforms, along with reprogramming factors, differentially regulate the induction of cornea-specific genes [PDF]

, 2016
PAX6 is the key transcription factor involved in eye development in humans, but the differential functions of the two PAX6 isoforms, isoform-a and isoform-b, are largely unknown.
Hayashi, Ryuhei, Kawasaki, Satoshi, Nakai, Kenta, Nishida, Kohji, Park, Sung-Joon, Quantock, Andrew J, Saito-Adachi, Mihoko, Sasamoto, Yuzuru, Suzuki, Yutaka, Tsujikawa, Motokazu   +9 more
core   +2 more sources

In vivo measurement of afferent activity with axon-specific calcium imaging. [PDF]

, 2018
In vivo calcium imaging from axons provides direct interrogation of afferent neural activity, informing the neural representations that a local circuit receives.
Broussard, Gerard Joey, Fridman, Marina, Ji, Na, Liang, Yajie, Meng, Guanghan, Petreanu, Leopoldo, Tian, Lin, Unger, Elizabeth K, Xiao, Xian   +8 more
core  

Epidemiologic investigation of immune-mediated polyradiculoneuropathy among abattoir workers exposed to porcine brain [PDF]

, 2003
Background In October 2007, a cluster of patients experiencing a novel polyradiculoneuropathy was identified at a pork abattoir (Plant A). Patients worked in the primary carcass processing area (warm room); the majority processed severed heads (head ...
Holzbauer, Stacy M., DeVries, Aaron S., Sejvar, James J., Lees, Christine H., Adjemian, Jennifer, McQuiston, Jennifer H., Medus, Carlota, Lexau, Catherine A., Harris, Julie R., Recuenco, Sergio E., Belay, Ermias D., Howell, James F., Buss, Bryan F., Hornig, Mady, Gibbins, John D., Brueck, Scott E., Smith, Kirk E., Danila, Richard N., Lipkin, W. Ian, Lachance, Daniel H., Dyck, P. James. B., Lynfield, Ruth   +21 more
core   +2 more sources

Generation of a TALEN-mediated, p63 knock-in in human induced pluripotent stem cells [PDF]

, 2017
The expression of p63 in surface ectodermal cells during development of the cornea, skin, oral mucosa and olfactory placodes is integral to the process of cellular self-renewal and the maintenance of the epithelial stem cell status.
Hayashi, R., Kobayashi, Y., Nishida, K., Quantock, Andrew J.   +3 more
core   +3 more sources

A visual reporter system for transgene screening and monitoring genome editing in tomato

Vegetable Research
The stable expression of integrated transgenes remains a major restriction in plant transformation, as different vector backbones and host contexts often lead to variable or silenced expression.
Ningkai An, Jinbo Wei, Shiliang Chen, Xiaoyue Yang, Kemeng Wu, Xinjie Zhou, Jie Wang, Shasha Wu, Shurong Wu, Chenyi Liu, Yueyue Fu, Jinyu Zhang, Weizhen Yi, Huijun Zhu, Chao Sun, Shuang Wu   +15 more
doaj   +1 more source

Enterovirusten tyypitys RT-qPCR-menetelmällä [PDF]

, 1999
Työn tarkoituksena oli optimoida toimiva ja herkkä RT-qPCR-menetelmä enterovirusten tyypittämiseksi monistamalla enterovirusgenomin VP1-aluetta. Optimoinnissa käytettiin näytteinä plasmidiin kloonattuja virusgenomeja ja virus-RNA:ta, jotka oli eristetty ...
Jaume Llistosella i Vidal, Jordi Vila i Garcia, Xavier Llimona i Pagès   +2 more
core   +1 more source