Results 61 to 70 of about 1,951 (164)

A viral metagenomic survey identifies known and novel mammalian viruses in bats from Saudi Arabia.

open access: yesPLoS ONE, 2019
Bats are implicated as natural reservoirs for a wide range of zoonotic viruses including SARS and MERS coronaviruses, Ebola, Marburg, Nipah, Hendra, Rabies and other lyssaviruses.
Nischay Mishra   +15 more
doaj   +1 more source

Development and application of a reverse transcription quantitative PCR assay for detection of Porcine Teschovirus

open access: yesVeterinarski arhiv (Tisak)
A rapid, specific, and sensitive quantitative PCR assay was developed for the detection of Porcine Teschovirus (PTV). Specific primers were designed on the basis of conserved regions of complete PTV genome sequences retrieved from GenBank, and a ...
Hanying Li   +13 more
semanticscholar   +1 more source

A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in Artemisia capillaris

open access: yesPlant Biotechnology Journal, Volume 24, Issue 1, Page 346-360, January 2026.
ABSTRACT Artemisia capillaris, a traditional Chinese medicinal plant, has displayed favourable effects in the treatment of jaundice, inflammation of the liver and cholecystitis for thousands of years. However, the biosynthesis of scoparone, the major active component in A. capillaris, remains unclear.
Fuyou Guo   +15 more
wiley   +1 more source

Rationally Designed TadA‐Derived Cytosine Editors Enable Context‐Independent Zebrafish Genome Editing

open access: yesAdvanced Science, Volume 12, Issue 39, October 20, 2025.
A next‐generation cytosine base editor (zTadCBE) and other variants are developed by combining the high‐efficiency (TadCBEa) and low‐indel (TadCBEMax) architectures, followed by the introduction of zebrafish‐optimized mutations (V82S, Q154R) in the TadA domain.
Wei Qin   +7 more
wiley   +1 more source

Metagenomic analysis of the RNA fraction of the fecal virome indicates high diversity in pigs infected by porcine endemic diarrhea virus in the United States

open access: yesVirology Journal, 2018
Background Emergence and re-emergence of porcine epidemic diarrhea virus (PEDV) in North America, Asia and Europe has caused severe economic loss to the global swine industry.
Qi Chen   +9 more
doaj   +1 more source

Immunohistochemical Distribution of Viral Antigens in Pigs Naturally Infected with Porcine Teschovirus

open access: yesJournal of Veterinary Medical Science, 2008
A distribution of porcine teschovirus (PTV) antigens in pigs naturally infected with PTV is presented using the method of immunohistochemical examination. In the nervous system, PTV antigens were found in the cytoplasm of neuronal cells and glial cells distributed in the spinal ventral horn and brain stem, and also in the cytoplasm of ganglion cells in
YAMADA, Manabu   +8 more
openaire   +3 more sources

Comparative analysis of two newly established Cre rat lines, NeuN‐Cre and Thy1‐Cre, for neurological research

open access: yesAnimal Models and Experimental Medicine, Volume 8, Issue 8, Page 1468-1479, August 2025.
We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li   +15 more
wiley   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

open access: yesExploration, Volume 5, Issue 4, August 2025.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang   +6 more
wiley   +1 more source

The complete genome of klassevirus – a novel picornavirus in pediatric stool

open access: yesVirology Journal, 2009
Background Diarrhea kills 2 million children worldwide each year, yet an etiological agent is not found in approximately 30–50% of cases. Picornaviral genera such as enterovirus, kobuvirus, cosavirus, parechovirus, hepatovirus, teschovirus, and ...
Ganem Donald   +6 more
doaj   +1 more source

Exchanging the order of carotenogenic genes linked by porcine teschovirus-1 2A peptide enable to optimize carotenoid metabolic pathway in Saccharomyces cerevisiae

open access: yesRSC Advances, 2018
The yeast Saccharomyces cerevisiae serves as a promising host for the production of a wide range of chemical compounds and fuels. Currently, simultaneous expression of several genes could be achieved via the use of 2A viral peptides, yet detailed ...
X. Jiao   +7 more
semanticscholar   +1 more source

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