Results 51 to 60 of about 1,599,874 (309)

A Combined Non-Destructive and Micro-Destructive Approach to Solving the Forensic Problems in the Field of Cultural Heritage: Two Case Studies

Applied Sciences, 2021
The present paper discusses the importance of non-destructive and micro-destructive technology in forensic investigations in the field of cultural heritage.
Michela Ricca, Maria F. Alberghina, Luciana Randazzo, Salvatore Schiavone, Antonio Donato, Maria P. Albanese, Mauro F. La Russa   +6 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

TESTING FOR EVOLUTIONARY RELATIONSHIP: AN APPLICATION OF MATHEMATICS IN MOLECULAR BIOLOGY [PDF]

COSMOS, 2005
The paper illustrates some mathematical problems that are motivated by molecular biological applications and the techniques that are used to address them. The context is that of detecting evolutionary relationship on the basis of molecular sequence data and of measuring its strength.
openaire   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease

Frontiers in Molecular Neuroscience
The Monoamine Oxidase-A (MAOA) EcoRV polymorphism (rs1137070) is a unique synonymous mutation (c.1409 T > C) within the MAOA gene, which plays a crucial role in Maoa gene expression and function.
Kai Xin Li, Kai Xin Li, Kai Xin Li, Kai Xin Li, Kai Xin Li, Lei Fan, Lei Fan, Lei Fan, Lei Fan, Hongjuan Wang, Hongjuan Wang, Hongjuan Wang, Yushan Tian, Yushan Tian, Yushan Tian, Sen Zhang, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu, Fanglin Liu, Fanglin Liu, Fanglin Liu, Fanglin Liu, Fanglin Liu, Huan Chen, Huan Chen, Huan Chen, Hongwei Hou, Hongwei Hou, Hongwei Hou   +31 more
doaj   +1 more source

Chylomicrons: Advances in biology, pathology, laboratory testing, and therapeutics

Clinica Chimica Acta, 2016
The adequate absorption of lipids is essential for all mammalian species due to their inability to synthesize some essential fatty acids and fat-soluble vitamins. Chylomicrons (CMs) are large, triglyceride-rich lipoproteins that are produced in intestinal enterocytes in response to fat ingestion, which function to transport the ingested lipids to ...
Josep Julve, Jesús M. Martín-Campos, Joan Carles Escolà-Gil, Francisco Blanco-Vaca   +3 more
openaire   +4 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source