Results 131 to 140 of about 10,239,739 (303)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Construction of a Heist (2014)

NECSUS, 2015
Henrike Lindenberger
doaj   +1 more source

EURL ECVAM Genotoxicity and Carcinogenicity Database of Substances Eliciting Negative Results in the Ames Test: Construction of the Database.

Mutat Res Genet Toxicol Environ Mutagen, 2020
Madia F, Kirkland D, Morita T, White P, Asturiol D, Corvi R.   +5 more
europepmc   +1 more source

Tractor Testing; PTO Test; Jeep

, 1949
"Willys Jeep being tested at Nebraska Tractor Test Laboratory." Willys-Overland Motors Jeep CJ-3A Universal is shown inside the tractor test lab. After WWII, with many jeeps being surplus and a lack of tractors, the Jeep as well as the Dodge Power wagon ...
Nebraska Tractor Test Laboratory
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Corrigendum to "EURL ECVAM genotoxicity and carcinogenicity database of substances eliciting negative results in the Ames test: Construction of the database" [Mutat. Res. 854-855 June-July (2020) 503199].

Mutat Res Genet Toxicol Environ Mutagen, 2020
Madia F, Kirkland D, Morita T, White P, Asturiol D, Corvi R.   +5 more
europepmc   +1 more source

Tractor Testing; Drawbar; Test Car

, 1920
"View of tractor and dynamometer car in 1920. Fred Laub driving. Lew Wallace in test car." The tractor is not identifiable. This load/test car was a second edition of the first open test car, which was called the bath-tub by the ...
Nebraska Tractor Test Laboratory
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Optimal Test Construction [PDF]

, 2005
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ford 1600 Diesel, test 1228

, 1976
The Ford 1600 Diesel is being driven on the tractor test track followed by the test car and an Oliver ...
Nebraska Tractor Test Laboratory
core