Results 71 to 80 of about 10,239,739 (303)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Test Construction for Mathematical Functions [PDF]
, 2008 The article deals with problems of testing implementations of mathematical functions working with floating-point numbers. It considers current standards' requirements to such implementations and demonstrates that those requirements are not sufficient for correct operation of modern systems using sophisticated mathematical modeling.
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
An Introduction to Criterion-Referenced Measurement
Canadian Journal of Education, 1976 L'auteur présente et définit le concept de la mesure en fonction de critères; il analyse ce qui caractérise les tests en fonction de critères à partir de quatre points : leur élaboration, leur fiabilité et leur validité, leur application et le guide qui
P.A. Cranton
doaj +2 more sources
autoFC: An R Package for Automatic Item Pairing in Forced-Choice Test Construction. [PDF]
Appl Psychol Meas, 2022 Li M, Sun T, Zhang B.
europepmc +1 more source
PCS-Q-G. Parental Caregiving Style Questionnaire – German Version
Der PCS-Q-G dient der retrospektiven Erfassung des elterlichen Fürsorgeverhaltens. In Analogie zum 3-Kategorien-Modell von Bindung unterscheidet das Instrument zwischen den drei Stilen „warm/aufmerksam“, „ambivalent/inkonsistent“ und „kalt/abweisend ...
Rohmann, E., Neumann, E.
core +1 more source
TEACHERS� BEHALF ON LANGUAGE TEST CONSTRUCTION
LLT Journal: A Journal on Language and Language Teaching, 2017 There are four steps necessarily to be conducted when designing multiple-choice test items, namely setting the objective, building both concise stems and options, determining one correct answer, employing item indices to accept or discarding items (Brown, 2004). As a matter of fact, most teachers in Aceh are not very well-informed about the fourth step
Nyak Mutia Ismail, Marisa Yoestara
openaire +4 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source