Results 31 to 40 of about 25,505 (287)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ames Test (Bacterial Reverse Mutation Test): Why, When, and How to Use

, 2014
20 páginas, 2 figuras y 4 tablas. The authors express their thanks to Dr. Oscar Herrero, Dr. Eduardo de la Peña Jr., Ms. Antonia Martinez, and the Institute of Agricultural Sciences (CSIC).The Salmonella typhimurium /mammalian microsome assay is the most
Pillco, Araceli, Eduardo de la Peña, Peña de Torres, Eduardo de la, Araceli Pillco   +3 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Comparative Epidemiological Studies on Gallbladder Cancer between Chile and Japan

Estudios Atacameños, 1998
Se ha realizado un estudio del cáncer vesicular entre 1991 y 1998 en Chile. Presentamos los principales hallazgos encontrados en esta investigación y se comparan con los datos equivalentes de Japón. 1) Hemos examinado el índice de mortalidad del cáncer
Masaharu Yamamoto, Iván Serra, A. Calvo, H. Watanabe, K. Endoh, N. Shibuya, K. Nakamura   +6 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Mutagenic activity of a fluorinated analog of the beta-adrenoceptor ligand carazolol in the Ames test

, 2000
S-1'[F-18]-Fluorocarazolol (FCAR) is a fluorinated analog of the nonmutagenic beta-blocker carazolol (CAR). Tn former studies FCAR proved to be suitable for quantification of beta-adrenoceptors in vivo with positron emission tomography (PET).
Doze, P, Vaalburg, W, P Doze, Elsinga, PH, de Vries, EFJ, A Van Waarde, de Vries, EFJ; id_orcid, Van Waarde, A, P.H Elsinga, W Vaalburg, Van Waarde, A; id_orcid, E.F.J de Vries   +11 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Evaluación ecotóxica y genotóxica de aguas residuales hospitalarias Ecotoxicological and genotoxic evaluation of hospital wastewaters

Acta Toxicológica Argentina, 2012
Los líquidos residuales provenientes de hospitales constituyen un riesgo potencial para los ecosistemas y la salud humana debido a la presencia de compuestos tóxicos y genotóxicos.
Anahí Magdaleno, Ángela B Juárez, Marta Paz, Carina Tornello, Lidia Núñez, Juan Moretton   +5 more
doaj  

Die Vorhersage der Schwierigkeit deutscher C-Test-Texte: Untersuchungen am Beispiel des onDaF [PDF]

Zeitschrift für Interkulturellen Fremdsprachenunterricht, 2016
C-Tests sind Lückentests zur schnellen und zuverlässigen Messung der allgemeinen Sprachkompetenz. Obwohl die Tests bereits hinsichtlich vieler verschiedener Aspekte untersucht wurden, konnte die Frage, warum manche C-Test-Texte schwieriger sind als andere, noch nicht hinreichend beantwortet werden.
openaire   +3 more sources