Results 41 to 50 of about 14,106,922 (303)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ABOUT ONE APPROACH OF TESTING GEOMETRICAL KNOWLEDGE SYSTEM BUILDING.

open access: yesÌнформаційні технології в освіті, 2014
The paper presents an approach to testing system building of procedural geometric knowledge, i.e. knowledge of basic computational formulas and skills to use them. This approach consists in constructing the mathematical models for each academic module in
M. Lvov
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Two-Dimensional Frequency Modulation Deception Jamming Against ISAR

open access: yesIEEE Access, 2019
This paper proposes a false target jamming method for countering ISAR based on two-dimensional frequency modulation. The target template is created according to the ISAR image of a true target.
Ning Tai   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Lifetime prediction of copper pillar bumps based on fatigue crack propagation

open access: yesFrontiers in Materials
2.5D package realizes the interconnection of multiple dies through Si interposers, which can greatly improve the data transmission rate between dies. However, its multi-layer structure and high package density also place higher reliability requirements ...
Yuege Zhou   +8 more
doaj   +1 more source

On designing and testing distributed virtual environments [PDF]

open access: yesConcurrency and Computation: Practice and Experience, 2016
SummaryDistributed real‐time (DRT) systems are among the most complex software systems to design, test, maintain, and evolve. The existence of components distributed over a network often conflicts with real‐time requirements, leading to design strategies that depend on domain‐specific and even application‐specific knowledge.
Arthur Valadares   +2 more
openaire   +3 more sources

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