Results 121 to 130 of about 11,258,936 (255)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tractor Testing; Belt Test; Allis Chalmers
, 1948 Official belt test no. 397 Allis-Chalmers HD19." The Allis-Chalmers HD-19 crawler on berlt power test inside the tractor test lab. Technician Joe Flamm stands measuring belt speed with a hand-held tachometer.
Nebraska Tractor Test Laboratory
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Test no. 394 Massey-Harris 55. 1948.
, 1948 Three-quarter view from the front of the Massey-Harris tractor on the test track.
Nebraska Tractor Test Laboratory
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Tractor Testing; Belt Power Test; Caterpillar
, 1949 Caterpillar D4 diesel during belt test. Caterpillar D4 diesel crawler inside the old tractor test lab with a belt running from the rear of the tractor to the dynamometer inside the control ...
Nebraska Tractor Test Laboratory
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
GPSPS. German Personal Sense of Power Scale
Die deutsche Adaptation GPSPS misst mit je 6 Items die subjektive Macht als Trait- oder State-Komponente sowie in verschiedenen Beziehungstypen. Reliabilität: Die interne Konsistenz lag zwischen α/ω = .78 und α/ω = .89.
Körner, R.
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source