Results 131 to 140 of about 704,956 (316)
Explaining the structure of inter-organizational networks using exponential random graph models: does proximity matter? [PDF]
A key question raised in recent years is which factors determine the structure of inter-organizational networks. While the focus has primarily been on different forms of proximity between organizations, which are determinants at the dyad level, recently ...
Tom Broekel, Matte Hartog
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Testing Simultaneous Planarity when the Common Graph is 2-Connected
Journal of Graph Algorithms and Applications, 2013 Two planar graphs G1 and G2 sharing some vertices and edges are simultaneously planar if they have planar drawings such that a shared vertex [edge] is represented by the same point [curve] in both drawings.
Bernhard Haeupler +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Heterogeneous Graph Transformer with Multi-View Representation Learning for Flaky Test Detection
ComputersContinuous Integration pipelines rely on large-scale automated testing to support rapid releases. However, flaky tests exhibit non-deterministic outcomes under an identical code and configuration, substantially increasing rerun costs and hindering fault ...
Peng Dai +3 more
doaj +1 more source
Using status messages in the distributed test architecture [PDF]
, 2008 If the system under test has multiple interfaces/ports and these are physically distributed then in testing we place a tester at each port. If these testers cannot directly communicate with one another and there is no global clock then we are testing ...
Hierons, RM
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The effects of random geometric graph structure and clustering on localizability of sensor networks
International Journal of Distributed Sensor Networks, 2017 Graph rigidity provides the conditions of unique localizability for cooperative localization of wireless ad hoc and sensor networks. Specifically, redundant rigidity and 3-connectivity are necessary and sufficient conditions for unique localizability of ...
Tolga Eren
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source