Results 141 to 150 of about 814,853 (265)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Construct validity in cross-cultural management research: classical test theory and latent trait theory approaches [PDF]

Problems and Perspectives in Management, 2013
Debi P. Mishra
doaj  

Evaluating the Insomnia Severity Index among South African first responders: evidence from classical test theory, Rasch, and Mokken analyses. [PDF]

Front Sleep
Pretorius TB, Padmanabhanunni A.
europepmc   +1 more source

Validating Insomnia Severity Index (ISI) in a Bangladeshi Population: Using Classical Test Theory and Rasch Analysis. [PDF]

Int J Environ Res Public Health, 2021
Mamun MA, Alimoradi Z, Gozal D, Manzar MD, Broström A, Lin CY, Huang RY, Pakpour AH.   +7 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

A Longitudinal Study on Development and Validation of the Prostate Cancer Scale Among the System of Quality of Life Instruments for Patients with Cancer (QLICP-PR V2.0) Based on Classical Test Theory and Generalizability Theory. [PDF]

Ann Surg Oncol
Wei W, Guo F, Zhang T, Chen Y, Li G, Luo J, Wan C.   +6 more
europepmc   +1 more source

Using path analysis to test theory of change: a quantitative process evaluation of the MapSan trial. [PDF]

BMC Public Health, 2021
Bick S, Buxton H, Chase RP, Ross I, Adriano Z, Capone D, Knee J, Brown J, Nalá R, Cumming O, Dreibelbis R.   +10 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Validation of the eHealth Literacy Scale Instrument in a Restless Legs Syndrome Population: Classical Test Theory and Rasch Analysis Study. [PDF]

J Med Internet Res
Georgsson M, Odzakovic E, Björk M, Kaldo V, Jernelöv S, Blom K, Ulander M, Fridlund B, Knutsson S, Sandlund C, Pakpour A, Broström A.   +11 more
europepmc   +1 more source

Functioning of the EROS-R Scale in a Clinical Sample of Psychiatric Patients: New Psychometric Evidence from the Classical Test Theory and the Item Response Theory. [PDF]

Int J Environ Res Public Health, 2022
Vilca LW, Chambi-Mamani EL, Quispe-Kana ED, Hernández-López M, Caycho-Rodríguez T.   +4 more
europepmc   +1 more source