Results 141 to 150 of about 819,082 (264)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Construct validity in cross-cultural management research: classical test theory and latent trait theory approaches [PDF]

Problems and Perspectives in Management, 2013
Debi P. Mishra
doaj  

Evaluating the Insomnia Severity Index among South African first responders: evidence from classical test theory, Rasch, and Mokken analyses. [PDF]

Front Sleep
Pretorius TB, Padmanabhanunni A.
europepmc   +1 more source

Validating Insomnia Severity Index (ISI) in a Bangladeshi Population: Using Classical Test Theory and Rasch Analysis. [PDF]

Int J Environ Res Public Health, 2021
Mamun MA, Alimoradi Z, Gozal D, Manzar MD, Broström A, Lin CY, Huang RY, Pakpour AH.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Validation of the eHealth Literacy Scale Instrument in a Restless Legs Syndrome Population: Classical Test Theory and Rasch Analysis Study. [PDF]

J Med Internet Res
Georgsson M, Odzakovic E, Björk M, Kaldo V, Jernelöv S, Blom K, Ulander M, Fridlund B, Knutsson S, Sandlund C, Pakpour A, Broström A.   +11 more
europepmc   +1 more source

Using path analysis to test theory of change: a quantitative process evaluation of the MapSan trial. [PDF]

BMC Public Health, 2021
Bick S, Buxton H, Chase RP, Ross I, Adriano Z, Capone D, Knee J, Brown J, Nalá R, Cumming O, Dreibelbis R.   +10 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Longitudinal Study on Development and Validation of the Prostate Cancer Scale Among the System of Quality of Life Instruments for Patients with Cancer (QLICP-PR V2.0) Based on Classical Test Theory and Generalizability Theory. [PDF]

Ann Surg Oncol
Wei W, Guo F, Zhang T, Chen Y, Li G, Luo J, Wan C.   +6 more
europepmc   +1 more source

Functioning of the EROS-R Scale in a Clinical Sample of Psychiatric Patients: New Psychometric Evidence from the Classical Test Theory and the Item Response Theory. [PDF]

Int J Environ Res Public Health, 2022
Vilca LW, Chambi-Mamani EL, Quispe-Kana ED, Hernández-López M, Caycho-Rodríguez T.   +4 more
europepmc   +1 more source