Results 31 to 40 of about 111,322 (239)
PharmaceuticsBackground/Objectives: Cancer is a major health concern involving abnormal cell growth. Combining anticancer agents can enhance efficacy and overcome resistance by targeting multiple pathways and creating synergistic effects.
Bianca Costa Maia-do-Amaral +12 more
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TRPV1 activation induces cell death of TM3 mouse Leydig cells
Journal of Animal Reproduction and Biotechnology, 2021 The role of transient receptor potential vanilloid receptor-1 (TRPV1) has been primarily investigated in pain sensory neurons. Relatively, little research has been performed in testicular cells.
Eun-Jin Kim +6 more
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Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells
mBio, 2019 Zika virus (ZIKV) is unique among mosquito-borne flaviviruses in its ability to be sexually transmitted. Persistent ZIKV infection in the testes, which are immune privileged organs, long after peripheral clearance suggests involvement of ...
Daniel P. Strange +7 more
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Testicular Ultrasound Analysis as a Predictive Tool of Ram Sperm Quality
Biology, 2022 Testicular ultrasound is a non-invasive technique that could be very useful for predicting ram seminal quality. Recent software developments allow macroscopic and microscopic evaluation of testicular parenchyma.
Melissa Carvajal-Serna +3 more
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The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Hepatic damage in residents of a major coal mining region in Brazil
Discover Public HealthCoal mining and the subsequent burning of coal release waste products that can accumulate in the environment and pose a threat to human health. Therefore, this study aims to evaluate hepatic damage by bilirubin, ALP, ALT, and GGT among men from the ...
Júlia Oliveira Penteado +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Fatty Acid Profiles in the Gonads of Red King Crab (Paralithodes camtschaticus) from the Barents Sea
Animals, 2023 Red king crab (Paralithodes camtschaticus) is a large shelf species native to the Pacific Ocean. Due to its high commercial value, this species was introduced into the Barents Sea, where it has formed a new population that now supports a stable ...
Alexander G. Dvoretsky +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source