The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao +7 more
wiley +1 more source
Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life [PDF]
To determine the origin of estrogens in infant blood, we measured estrone (E1) and estradiol (E2) in the gonads of 50 girls and 64 boys who died suddenly between birth and 2 yr of age as well as in the adrenals of 18 of these infant girls and 16 of the ...
Eisenmenger, Wolfgang +4 more
core
The evolution of large testes: Sperm competition or male mating rate?
A positive relationship across species between the extent to which females mate with more than one male and relative testes mass has been demonstrated in a wide range of vertebrate taxa and certain insects.
Parker, Darren James +2 more
core +1 more source
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou +10 more
wiley +1 more source
The effect of oxidized dextran on the morphology of Wistar rat testes under acute toxic effects
The study of the viability of the spermatogenic epithelium in case of toxic lesions and their correction in experiment is a key factor for understanding the possibilities of restoring reproductive function in conditions of increasing technogenic ...
O. P. Molodykh +6 more
doaj +1 more source
Histological and Functional study of white male mice testes and kidney treated with Tecrium Polium aqueous extract [PDF]
The oral administration of the aqueous extract of Teucrium polium to amature male mice in daily oral doses of 50 mg/kg body weight (group II) and 100mg/kg body weight (group III) for eight consecutive weeks were resulted insignificant increase ...
Wasnaa Hatif Mohammed
doaj +1 more source
To Test or Not to Test, That Is the Question [PDF]
Physicians’ primary responsibility has always been to provide the best care for their individual patients, but the proliferation of modern tests and treatments has complicated their task. With so many options, it is often hard during an office visit to know whether to order a test and what to do with the results. And the ever-rising cost of health care
openaire +2 more sources
Percentuais de frequência cardíaca máxima, consumo máximo de oxigênio e pico de velocidade em atletas de futebol e futsal: comparação entre testes de campo e laboratório [PDF]
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-graduação em Educação Física, Florianópolis, 2009Objetivo: analisar as relações entre %FCmax, %VO2max e %PV em jogadores de equipes profissionais de ...
Brun, Gilson
core
Evolutionary trade-offs between testes size and parenting in Neotropical glassfrogs. [PDF]
In males, large testes size signifies high sperm production and is commonly linked to heightened sperm competition levels. It may also evolve as a response to an elevated risk of sperm depletion due to multiple mating or large clutch sizes.
Ringler, Eva +7 more
core +1 more source

