Results 61 to 70 of about 268,034 (314)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Age-Dependent Expression of Humanin in the Bull (Bos Taurus) Testis and Its Potential Role in Regulating Hormonal Status, Oxidative Stress and MicroRNA Expression

The Iraqi Journal of Veterinary Medicine
Humanin (HN), a mitochondrial-derived peptide with cytoprotective functions, has not been thoroughly investigated in the bull gonad. This study characterized the developmental localization of HN in the bull testis and its relationship with hormonal ...
Ali Louei Monfared, Alaa Rahman Ghyadh
doaj   +1 more source

Age-related morphological peculiarities of human testes

, 2021
This study aimed the comparison of the isolated testes size, volume, weight and density changes with age and establishing the suitability of three formulas of testicular volume calculation for 18-50 and 51-70-year-old men groups.
Gasiliunas, D., Juodžiukynienė, Nomeda, Žilaitienė, Birutė, Vitkus, Aleksandras, Lasienė, Kristina, Dabužinskienė, Anita   +5 more
core   +2 more sources

Avaliação de desempenho diagnóstico dos testes laboratoriais para sífilis em doadores de sangue de Santa Catarina em 2009 a 2012 [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Saúde Coletiva, Florianópolis, 2013.Introdução: A triagem sorológica, em doadores de sangue, representasignificado estratégico para
Baião, Aysla Marcelino
core  

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Ginger attenuated di (n-butyl) phthalate-induced reproductive toxicity in pubertal male rabbits

World Rabbit Science, 2017
This study was conducted to investigate the toxic effects of di (n-butyl) phthalate (DBP) on reproductive functions in male rabbits and the probable protective role of ginger.
S. S. Oda, R. S. Waheeb
doaj   +1 more source

The Protective Role of Poplar Propolis Against Alcohol-Induced Biochemical and Histological Changes in Liver and Testes Tissues of Rats

Erciyes Medical Journal, 2020
Objective: This study evaluated the biochemical and histopathological effects of propolis oil extract on liver and testicular tissue in rats subjected to alcohol toxicity.
Numan Baydilli, Emre Can Akınsal, Züleyha Doğanyiğit, Oğuz Ekmekçioğlu, Sibel Silici   +4 more
doaj   +1 more source

The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR

, 2012
Microcystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish.
Zhao, Yanyan, Jun, Chen, Xie, P (reprint author), Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China, Cai, Yan, Zhao, Sujuan, Xiong, Qian, Li, Guangyu, Xie, Ping   +7 more
core   +1 more source

IPBrick- Plataforma de testes automáticos [PDF]

, 2017
A IPBRICK SA possui uma checklist com a descrição dos testes e tarefas que são executadas manualmente com a intenção de testar todas as aplicações e software desenvolvidos na empresa. Alguns destes testes são executados recorrentemente sempre que é feito
Sérgio Manuel da Costa Reis
core   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source