Results 41 to 50 of about 18,929 (249)

Testicular biopsy in prepubertal boys:a worthwhile minor surgical procedure? [PDF]

, 2016
No consensus exists regarding the precise role of testicular biopsy in prepubertal boys, although it is considered useful for assessing the potential consequences of undescended testes on fertility.
Faure, Alice, Mike O'Brien, Bouty, Aurore, Hutson, John, Alice Faure, O'Brien, Mike, Jorgen Thorup, Thorup, Jorgen, Aurore Bouty, John Hutson, Yves Heloury, Heloury, Yves   +11 more
core   +1 more source

Multiparametric Ultrasound Findings of Testicular Sarcoidosis. [PDF]

J Ultrasound Med
Objectives To characterize the multiparametric ultrasound (MPUS) features of testicular sarcoidosis, incorporating greyscale, color Doppler ultrasound (CDUS), contrast‐enhanced ultrasound (CEUS), and strain elastography (SE), and to assess their collective diagnostic value.
Liu H, Abudalo R, Salahia G, Yusuf GT, Huang DY, Sidhu PS.   +5 more
europepmc   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Use of new automated biopsy device for percutaneous testicular biopsy. A preliminary clinical experience. [PDF]

, 1998
Testicular biopsy is indicated in the azoospermic patients to determine if the cause of azoospermia is ductal obstruction or testicular pathology and in certain patients who have severe oligozoospermia.
Cikili N., Apaydm E., Ilbey O., Gürsan A., Semerci B.   +4 more
core  

Gonadoblastoma Arising in Undifferentiated Gonadal Tissue within Dysgenetic Gonads [PDF]

, 2006
Purpose: The purpose of the study was to define the histological origin of gonadoblastomas, allowing the identification of high-risk patients. Experimental Design: Sixty paraffin-embedded gonadectomy or gonadal biopsy samples of 43 patients with ...
Kula, Krzysztof, Looijenga, L. H. J., Faradz, Sultana M.H., Wolffenbuttel, K. P., Cools, Martine, Slowikowska-Hilczer, J., Slowikowska-Hilczer, Jolanta, Cools, M., Bourguignon, Jean-Pierre, Stoop, Hans, Drop, Stenvert L. S, Drop, S. L. S., Oosterhuis, J. W., Kersemaekers, A. M. F., Faradz, S. M. H., Kersemaekers, Anne-Marie F., Looijenga, Leendert H. J, Wolffenbuttel, Katja P, Stoop, H., Kula, K., Oosterhuis, J. Wolter   +20 more
core   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Testicular Biopsy in Hypogonadal Male I. Basic Introductive Articles [PDF]

, 1958
In a series of my studies, observation on the t e s t icular biopsy of hypogonadal male will be presented. In this present paper, a basic introductive survey is discussed. Recently, information of the male hypogonadism has been considerab l y accumulated
酒徳, 治三郎
core  

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Urology Research and Practice, 2019
Objective: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat ...
Aydan Özgörgülü, Aysun Sayılmaz, Yasemin Yuyucu Karabulut   +2 more
doaj   +1 more source

Comparison of Relapse Risk Prediction Models During Active Surveillance in Stage I Seminoma: A Retrospective Multicenter Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT To improve the prediction of relapse for clinical stage I seminoma, we aimed to validate the Boormans model (incorporating tumor size, rete testis invasion, and lymphovascular invasion) against the conventional classification (tumor size > 4 cm/rete testis invasion).
Andreas Banner, Eveline Daetwyler, Stefanie Fischer, Stephanie Schöpfer‐Schwab, Karl Pemberger, Michael Scholz, Kathrin Olesch, David Oswald, Angelina Strauch, Tim Nestler, Lukas Koren‐Wagner, Robin Zeder, Clemens Mikulits, Sebastian Lenart, Christoph Seidel, Angelika Terbuch   +15 more
wiley   +1 more source