Results 41 to 50 of about 341,009 (238)

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

open access: yesUrology Research and Practice, 2019
Objective: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat ...
Aydan Özgörgülü   +2 more
doaj   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang   +16 more
wiley   +1 more source

Breakpoint Mapping and Disrupted Gene Identification in Azoospermic Patients With Chromosomal Balanced Translocation by Nanopore Sequencing

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study employed nanopore long‐read sequencing to achieve single‐base‐pair resolution breakpoint mapping in azoospermic patients with chromosomal balanced translocations, revealing cryptic breakpoints and an inverted insertion undetectable by conventional karyotyping.
Jian Zhang   +3 more
wiley   +1 more source

Testicular Biopsy in Hypogonadal Male I. Basic Introductive Articles [PDF]

open access: yes, 1958
In a series of my studies, observation on the t e s t icular biopsy of hypogonadal male will be presented. In this present paper, a basic introductive survey is discussed. Recently, information of the male hypogonadism has been considerab l y accumulated
酒徳, 治三郎
core  

Plasma Steroid Trajectories From Day‐of‐Surgery Baseline After Robot‐Assisted Radical Prostatectomy for Prostate Cancer

open access: yesThe Prostate, EarlyView.
ABSTRACT Background Circulating steroid trajectories after robot‐assisted radical prostatectomy are poorly characterized from the day‐of‐surgery baseline, and relevant biology extends beyond testosterone and dihydrotestosterone to adrenal‐derived 11‐oxygenated androgens and steroid conjugate turnover.
Jiri Heracek   +8 more
wiley   +1 more source

Role of testicular fine‐needle aspiration in the modern male reproductive urologist′s practice

open access: yesUroPrecision, EarlyView.
Abstract Background Azoospermia affects 10%–15% of infertile men, with non‐obstructive azoospermia (NOA) most often managed by microdissection testicular sperm extraction (mTESE). Despite AUA/ASRM guidelines recommending mTESE, some urologists employ testicular fine‐needle aspiration (TFNA) mapping as a diagnostic adjunct.
Parth Joshi   +3 more
wiley   +1 more source

Azospermia and Testicular Biopsy

open access: yesEurasian Journal of Medicine, 2019
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Mustafa Güvendi   +2 more
doaj  

Is testicular microdissection the only way to retrieve sperm for non-obstructive azoospermic men?

open access: yesFrontiers in Reproductive Health, 2022
Men presenting with non-obstructive azoospermia are the most challenging clinical scenario for an infertile couple. Intracytoplasmic Sperm Injection (ICSI) with testicular sperm retrieval gave a chance for biological fatherhood once sperm can be found ...
Marcelo Vieira   +2 more
doaj   +1 more source

External Genital Cutaneous Sarcoidosis Mimicking Lichen Sclerosus

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT Although external genital cutaneous sarcoidosis is rare, it can closely resemble lichen sclerosus (LS) and delay diagnosis. We report a case of a 69‐year‐old woman with long‐standing vulvar symptoms and LS‐like pallor of the labia minora and clitoris. Biopsy showed non‐caseating granulomas with negative infection stains, consistent with vulvar
Enakshi Mudalige, Annabel Stevenson
wiley   +1 more source

A Unified Machine Learning Model for Relapse Prediction in Clinical Stage I Testicular Cancer

open access: yesAndrology, EarlyView.
ABSTRACT Background Approximately one‐fourth of patients with clinical stage I testicular cancer relapse. For decades, risk stratification has been based on different tumor characteristics for seminomas and non‐seminomas. Previous studies primarily used Cox proportional‐hazards models and included only a limited number of variables.
Thomas Wagner   +7 more
wiley   +1 more source

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