Results 71 to 80 of about 18,929 (249)

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

Predictive factors of a successful testicular biopsy and subsequent clinical pregnancy [PDF]

, 2012
Forecast of success with testicular sperm extraction and intracytoplasmic sperm injection (ICSI) remains unknown, as predictive factors have rarely been studied.
Vendeira, P., Botelho, F., Tomada, N., Carvalho, A., Leite, R., Figueiredo, Luís Pacheco   +5 more
core   +1 more source

Prediction of testicular histology in azoospermia patients through deep learning-enabled two-dimensional grayscale ultrasound

Asian Journal of Andrology
Testicular histology based on testicular biopsy is an important factor for determining appropriate testicular sperm extraction surgery and predicting sperm retrieval outcomes in patients with azoospermia.
Jia-Ying Hu, Zhen-Zhe Lin, Li Ding, Zhi-Xing Zhang, Wan-Ling Huang, Sha-Sha Huang, Bin Li, Xiao-Yan Xie, Ming-De Lu, Chun-Hua Deng, Hao-Tian Lin, Yong Gao, Zhu Wang   +12 more
doaj   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Testicular neoplasia in undescended testes of cryptorchid boys-does surgical strategy have an impact on the risk of invasive testicular neoplasia?

The Turkish Journal of Pediatrics, 2004
We investigated whether or not surgical strategy has an impact on the risk of invasive testicular neoplasia in cases of cryptorchidism. We made a database study of the incidence of testicular neoplasia at surgery for cryptorchidism in childhood ...
Dina Cortes, Jorgen Thorup, Bodil Laub Petersen   +2 more
doaj  

Limited Clinical Impact of Androgen Receptor Repeat Length (CAG and GGC) in Klinefelter Syndrome: A Multivariable Analysis

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS) is characterized by marked phenotypic heterogeneity that might be influenced by genetic modifiers, including androgen receptor (AR) repeat length (CAGn and GGCn). The clinical relevance of these repeat lengths in patients with KS before testosterone replacement therapy (TRT) remains unclear.
Andrea Graziani, Alberto Scala, Maria Santa Rocca, Cinzia Vinanzi, Giuseppe Grande, Andrea Di Nisio, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +8 more
wiley   +1 more source

The prognostic value of testicular biopsy in childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group. [PDF]

, 1990
One of the objectives of Childrens Cancer Study Group (CCSG) study 141 (CCG-141) was to determine the frequency of occult testicular leukemia (TL) after 3 years of disease-free survival (DFS) and to retreat boys with occult TL to prolong their ...
H N Sather, D R Miller, V C Albo, S L Leikin, N F Palmer, G D Hammond   +5 more
core   +1 more source

Evaluation of sperm retrieval rate with bilateral testicular sperm extraction in infertile patients with azoospermia

Iranian Journal of Reproductive Medicine, 2015
Background: About 10% to 15% of infertile men have azoospermia, which could be obstructive or non-obstructive. Diagnostic biopsy from the testis and recently testicular sperm extraction (TESE) are the most precise investigations in these patients ...
Mohammad Reza Moein, Mahmoud Reza Moein, Jalal Ghasemzadeh, Soheila Pourmasoumi   +3 more
doaj  

Segmental testicular infarction: Case series and brief literature review of a great mime

Urology Annals, 2019
Segmental testicular infarction is rare, and the etiology is mostly idiopathic. We report a case series of four young patients, one of them with metachronous bilateral disease, presenting with an acute scrotum and treated with a testis-sparing approach ...
Franco Palmisano, Mariapia Serrago, Andrea Gallioli, Vito Lorusso, Franco Gadda, Matteo Giulio Spinelli, Emanuele Montanari   +6 more
doaj   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source