Results 51 to 60 of about 3,327,559 (283)

Cancer treatment and gonadal function : experimental and established strategies for fertility preservation in children and young adults [PDF]

, 2015
Copyright © 2015 Elsevier Ltd. All rights reserved.Preservation of gonadal function,is an important priority for the long-term health of cancer survivors of both sexes and all ages at treatment..
Mitchell, Rod T, Anderson, Richard A, Spears, Norah, Wallace, W Hamish B, Kelsey, Thomas W, Telfer, Evelyn E, Kelsey, Thomas W; id_orcid   +6 more
core   +1 more source

Metal Compound‐Based Non‐Enzymatic Electrochemical Cholesterol Sensors: Emerging Materials and Mechanistic Insights

Advanced Materials Interfaces, EarlyView.
This review discusses recent progress in metal complex‐based, non‐enzymatic electrochemical sensors for cholesterol detection. We examine metal oxides, metal sulfides, and hybrid nanomaterials, highlighting their catalytic mechanisms and material design strategies.
Longfei (Jack) Yin, Chao‐Tsen (Rora) Chen, Jacopo Giaretta, Thanh‐Qua Nguyen, Hoang‐Phuong Phan, Fariba Dehghani, Syamak Farajikhah   +6 more
wiley   +1 more source

Testicular parenchymal abnormalities in Klinefelter syndrome: a question of cancer? Examination of 40 consecutive patients

Asian Journal of Andrology, 2015
Klinefelter syndrome (KS) is a hypergonadotropic hypogonadism characterized by a 47, XXY karyotype. The risk of testicular cancer in KS is of interest in relation to theories about testicular cancer etiology generally; nevertheless it seems to be low. We
Giacomo Accardo, Gianfranco Vallone, Daniela Esposito, Filomena Barbato, Andrea Renzullo, Giovanni Conzo, Giovanni Docimo, Katherine Esposito, Daniela Pasquali   +8 more
doaj   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors. [PDF]

Andrology
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Kanetsky PA, Almstrup K, Cherlin S, Cortessis VK, Ferlin A, Gietema JA, González-Neira A, Grotmol T, Hamilton RJ, Haugen TB, Kiemeney LA, Kim J, Krausz C, Lessel D, Lothe RA, Nead KT, Nsengimana J, Poynter JN, Rajpert-DeMeyts E, Richiardi L, Schwartz SM, Skotheim RI, Stewart DR, Turnbull C, Wiklund F, Zheng T, Nathanson KL, McGlynn KA, Testicular Cancer Consortium.   +28 more
europepmc   +2 more sources

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Testicular cancer: The Most Common Malignancy in Young Men – A Review of Current Knowledge on Diagnosis and Treatment

Journal of Education, Health and Sport
Background. Testicular cancer is a rare malignancy that primarily affects young men and requires early diagnosis. The diagnosis is based on clinical tests, imaging tests and measurement of tumor markers. Treatment consists mainly of surgery, and further
Kamila Krycia, Karolina Mazur , Karolina Różycka , Magdalena Mulawa, Aleksandra Gałuszka, Emilia Piaszczyńska , Dominika Matacz , Sandra Drabik, Maja Gałuszka , Adrianna Adamczyk   +9 more
doaj   +1 more source

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

Advanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin, Chaojie Lai, Qingyan Zhou, Ruilin Wang, Yiping Tong, Wentao Chen, Nikola Rabrenovic, Tingyu Zhang, Xinrong Ren, Chengchen Huang, Jiawen Chen, Ran Li, Luyang Yu, Massimiliano Mazzone, Wenbin Zhang, Guosheng Fu, Min Shang   +16 more
wiley   +1 more source

Building families—Implementing balanced sexual and reproductive health

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning and family building.
Peter Y. Liu, Edgar Mocanu, Linda Giudice, Marcos Horton, Meletios P. Nigdelis, Antti Perheentupa, Andrea Sansone, Giovanni Corona, Luca Gianaroli, Dimitrios G. Goulis   +9 more
wiley   +2 more sources