Results 71 to 80 of about 4,783,149 (369)
Extra-gonadal germ cell tumour – what about the testis! [PDF]
, 2011 Extra-gonadal germ cell tumours (EGGCT) are rare. Therefore further investigations of the testis is aimed at sourcing a possible primary origin of gonadal tumour. Over the years, various case series on EGGCT have been reported questioning its true nature
Christopher CKH, +5 more
core
Advanced Science, EarlyView.MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li +10 more
wiley +1 more source
Will men tie their violet ribbons? Testicular cancer and testicular self-examination
BioMedica, 2022 The American Association for Cancer Research has declared the month of April as the global awareness month of Testicular Cancer (TC). Worldwide, TC is the most frequently reported malignancy in males aged 20 – 40 years.
Haseeb Mehmood Qadri, Fahad Qayyum
doaj +1 more source
On the Origin of Testicular Germ Cell Tumors: From Gonocytes to Testicular Cancer
Frontiers in Endocrinology, 2019 Human primordial germ cells (PGCs) have been described in the yolk sac wall around the beginning of the third week. From week 4 to 5, they migrate under control of SCF/c-KIT signaling pathway to the genital ridge, where they become gonocytes.
T. Baroni +4 more
semanticscholar +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
The surprising implications of familial association in disease risk
, 2017 Background: A wide range of diseases show some degree of clustering in families; family history is therefore an important aspect for clinicians when making risk predictions.
Aalen, Odd O. +2 more
core +1 more source
Advanced Science, EarlyView.The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai +15 more
wiley +1 more source
Loss of Nuclear Functions of HOXA10 Is Associated With Testicular Cancer Proliferation
Frontiers in Oncology, 2018 Background: HOXA10 is a key transcriptional factor that regulates testis development as reported from previous transgenic mouse models and human inherited diseases. However, whether it also plays important roles in promoting the development of testicular
Ruiqi Chen +7 more
doaj +1 more source
Psychological aspects of information seeking on the Internet [PDF]
, 2002 Two studies are presented that investigate information seeking behaviour on the Internet. In Study One, soccer fans’ information seeking on the World Wide Web (WWW) is investigated. In Study Two, access rates to a cancer information website are analysed.
Banyard, P, Joinson, A
core +1 more source
Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón +10 more
wiley +1 more source