Results 181 to 190 of about 2,277,679 (245)

Multidimensional Determinants of Quality of Life in Men With Klinefelter Syndrome: A Narrative Review of Workshop Evidence

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS), typically characterized by a 47, XXY karyotype, is the most common sex chromosomal aneuploidy in males, with a prevalence of approximately one in 600–660 individuals. Despite its frequency, the syndrome remains significantly underdiagnosed, with 50%–75% of affected individuals never receiving a clinical ...
Francesca Allosso, Lucia Digitale Selvaggio, Daniela Pasquali   +2 more
wiley   +1 more source

Lower Systolic Blood Pressure in 67 Boys With Klinefelter Syndrome Compared to 1842 Healthy Danish Boys

Andrology, EarlyView.
ABSTRACT Objective Our objective was to develop age‐ and height‐specific reference ranges for blood pressure, pulse pressure and mean arterial pressure in healthy boys and to compare these to measurements in patients with Klinefelter syndrome followed longitudinally through childhood and adolescence. Design Cohort study consisting of a population‐based
Andrés Felipe Ø. Fritzbøger, Riccardo Battiston, Cecilie N. Larsen, Anna Sophie L. Kjaer, Klaus Juul, Ida M. Schmidt, Jørgen H. Petersen, Katharina M. Main, Anders Juul, Lise Aksglaede   +9 more
wiley   +1 more source

Canine desexing attitudes and practices of Australian veterinarians: A cross‐sectional survey

Australian Veterinary Journal, EarlyView.
Canine desexing is one of the most common small animal surgical procedures in Australia, yet little is known about current practices. This study characterised attitudes, practitioner recommendations and surgical practices for routine canine desexing among Australian veterinarians using an online cross‐sectional survey (n = 107). Respondent demographics
S. Impey, M. Blevins, G. Chung, A. Goh, P. Rak   +4 more
wiley   +1 more source

The effect of time to nephrectomy on cancer‐specific mortality in pathological T stage (pT)1b–2 renal cancer

BJU International, EarlyView.
Objective To assess the impact of prolonged time to surgery on cancer‐specific mortality (CSM) in patients with pathological T stage (pT)1b–2 N0M0 renal cell carcinoma (RCC) treated with nephrectomy (either partial [PN] or radical [RN]). Within the Surveillance, Epidemiology and End Results (SEER) database (2004–2021), we tested the effect of time to ...
Michele Nicolazzini, Federico Polverino, Leonardo Quarta, Maximilian Filzmayer, Michele Petix, Calogero Catanzaro, Nick Lee, Jordan A. Goyal, Nicola Longo, Gennaro Musi, Felix K. H. Chun, Alberto Briganti, Riccardo Schiavina, Shahrokh F. Shariat, Carlotta Palumbo, Alessandro Volpe, Fred Saad, Pierre I. Karakiewicz   +17 more
wiley   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Higher LSD1 in Non‐Seminomatous Germ Cell Tumors and LSD1 Inhibition by NCL1 Suppresses Embryonal Carcinoma Growth

Cancer Science, EarlyView.
LSD1 expression was higher in non‐seminomatous than in seminomatous testicular germ cell tumor components. In embryonal carcinoma models, selective LSD1 inhibition by NCL1 induced epigenetic and apoptotic responses, reduced viability including in cisplatin‐adapted cells, and suppressed early xenograft outgrowth, supporting LSD1 as a potential ...
Nobuhiko Shimizu, Toshiki Etani, Taku Naiki, Aya Naiki‐Ito, Yosuke Sugiyama, Takashi Nagai, Akihiro Murakami, Hiroyuki Kato, Toshiharu Morikawa, Maria Aoki, Masakazu Gonda, Hiroko Suzuki, Yohei Tsubouchi, Daiki Ishikawa, Takayoshi Suzuki, Satoru Takahashi, Takahiro Yasui   +16 more
wiley   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

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TESTICULAR ACTIVITY IN CUSHING'S DISEASE

Acta Endocrinologica, 1979
ABSTRACT Plasma testosterone levels were suppressed in 6 of 8 mature male patients with Cushing's disease, all of whom complained of loss of libido and decreased sexual potency. Gonadotrophin levels, both under basal conditions and in response to LH-RH, were generally normal.
T J, McKenna, D, Lorber, A, Lacroix, D, Rabin   +3 more
openaire   +2 more sources

Testicular Inflammatory Diseases in the Buck

Journal of Comparative Pathology, 2009
Introduction: Orchitis and epididymitis have been poorly studied in the buck. Bacteria and protozoa have been reported as main causative agents. Materials and Methods: A retrospective study was performed on caprine testes registered in the archive of the department. Testes were grossly and microscopically evaluated.
MARINO, Gabriele, CATONE, Giuseppe, BARNA, ALESSANDRA, Russo M, ZANGHI', Antonina   +4 more
openaire   +2 more sources

Testicular hamartomas in Cowden disease

Journal of Clinical Ultrasound, 2003
AbstractWe report a case of testicular hamartomas in association with Cowden disease. Clinical examination of the patient, a 39‐year‐old man, revealed a palpable mass in the right side of the scrotum. Sonographic examination showed that the mass was either a spermatocele or an epididymal cyst and that multiple hyperechoic lesions were present in both ...
Christopher, Lindsay, Lisa, Boardman, Michael, Farrell   +2 more
openaire   +2 more sources