Results 101 to 110 of about 70,701 (334)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

Metastatic Potential of Small Testicular Germ Cell Tumors: Implications for Surveillance of Small Testicular Masses

open access: yesEuropean Urology Open Science, 2022
Incidental detection of urogenital tumors has increased in recent decades owing to the greater use of ultrasonography and cross-sectional imaging. For patients with low-risk prostate cancer or small renal masses, active surveillance represents a valid ...
Manolis Pratsinis   +22 more
doaj  

Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review [PDF]

open access: yes, 2007
Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of oxaliplatin in patients with ...
Bokemeyer   +65 more
core   +2 more sources

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

open access: yesOncoTarget, 2016
Testicular germ cell tumors (TGCTs) are the most common cancers of young males. A substantial portion of TGCT patients are refractory to cisplatin. There are no effective therapies for these patients, many of whom die from progressive disease.
C. Albany   +16 more
semanticscholar   +1 more source

Food Toxicology and Safety: Evaluating Dietary Risks and Functional Ingredients

open access: yesFood Bioengineering, EarlyView.
The pyramid's foundation reminds us that true health begins with daily habits—engage in 30–60 min of physical activity, nurture social connections and secure 7–9 h of restorative sleep each night to support metabolism, mood regulation, and hormonal balance—while continuously hydrating with 8–12 glasses of water and unsweetened herbal infusions (green ...
Sujaritha Jayaraj   +5 more
wiley   +1 more source

The perioperative outcomes of retroperitoneal lymph node dissection in Germany for patients with testicular cancer: Results from the GRAND study

open access: yesInternational Journal of Cancer, EarlyView.
What's new? This nationwide analysis explores the recent trends and perioperative outcomes of retroperitoneal lymph node dissection for testicular cancer, stratified by surgical approach, prior chemotherapy, and hospital caseload. Since 2005, the number of patients undergoing retroperitoneal lymph node dissection for testicular cancer has decreased ...
Nikolaos Pyrgidis   +12 more
wiley   +1 more source

Diagnostic value of qualitative and strain ratio elastography in the differential diagnosis of non-palpable testicular lesions [PDF]

open access: yes, 2016
The purpose of this study was to evaluate prospectively the accuracy of qualitative and strain ratio elastography (SE) in the differential diagnosis of non-palpable testicular lesions.
BARBAGALLO, FEDERICA   +12 more
core   +1 more source

Pulmonary toxicity in children, adolescents, and young adults with testicular germ cell tumors: A population‐based retrospective matched cohort study

open access: yesInternational Journal of Cancer, EarlyView.
What New? Testicular germ cell tumors are highly curable, but the treatments can have lasting impacts. As more young people are surviving these tumors, it is important to understand the lifelong toxicities of these treatments. Here, the authors evaluated the risks of acute and late pulmonary toxicities among children, adolescents, and young adults ...
Rand Ajaj   +8 more
wiley   +1 more source

Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results [PDF]

open access: yes, 2016
Aim: To report long term oncologic outcomes after adjuvant radiotherapy (RT) for stage I seminoma. Method: We reviewed the complete data set for all patients treated at our institute between 1988 and 2005 for stage I seminoma with adjuvant RT after ...
De Felice, Francesca   +4 more
core   +2 more sources

Etiologic Factors in Testicular Germ-Cell Tumors [PDF]

open access: yesFuture Oncology, 2009
Globally, testicular cancer incidence is highest among men of northern European ancestry and lowest among men of Asian and African descent. Incidence rates have been increasing around the world for at least 50 years, but mortality rates, at least in developed countries, have been declining.
Michael B. Cook, Katherine A. McGlynn
openaire   +3 more sources

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