Results 81 to 90 of about 5,359,290 (244)

Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors [PDF]

, 1999
We have cloned and characterized a cDNA encoding a new human serine proteinase, testisin, that is abundantly expressed only in the testis and is lost in testicular tumors.
Antalis, T., Stuttgen, M., Loveland, K. A. L., Dickinson, Joanne L., Sutherland, Grant R., Nicol, D., Eyre, H., Normyle, J., Hooper, John D., Lakoski-Loveland, Kate A., Douglas, Meaghan L., Eyre, Helen J., Hooper, J. D., Stuttgen, Melanie A., Dickinson, J., Sutherland, G., Dickinson, J. L., Eyre, H. J., Hooper, J., Normyle, John F., Scarman, A., Antalis, T. M., Nicol, David L., Scarman, A. L., Stuttgen, M. A., Douglas, M., Loveland, K., Douglas, M. L., Antalis, Toni M., Normyle, J. F., Sutherland, G. R., Scarman, Anthony L., Nicol, D. L.   +32 more
core  

Molecular characterization of testicular germ cell tumors using tissue microdissection

, 2021
Testicular germ cell tumors are among the most common malignancies seen in children and young adults. Genomic studies have identified characteristic molecular profiles in testicular cancer, which are associated with histologic subtypes and may predict ...
Montironi R., Santoni M., Adra N., Mann S. A., Cheng L., Davidson D. D., Zhang S., Albany C., Lopez-Beltran A., Chovanec M., Wang M., Cimadamore A.   +11 more
core   +1 more source

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

A Unified Machine Learning Model for Relapse Prediction in Clinical Stage I Testicular Cancer

Andrology, EarlyView.
ABSTRACT Background Approximately one‐fourth of patients with clinical stage I testicular cancer relapse. For decades, risk stratification has been based on different tumor characteristics for seminomas and non‐seminomas. Previous studies primarily used Cox proportional‐hazards models and included only a limited number of variables.
Thomas Wagner, Ramtin Zargari Marandi, Jakob Lauritsen, Daniel Dawson Murray, Mikkel Bandak, Birgitte Grønkær Toft, Dan Berney, Gedske Daugaard   +7 more
wiley   +1 more source

HNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors. [PDF]

, 2020
Hepatocyte Nuclear Factor 1 beta (HNF1β) is a transcription factor which plays an important role during early organogenesis, especially of the pancreato-biliary and urogenital tract.
Christiansen, Ailsa, Gallo, Alessandra, Hermanns, Thomas, Bode, Peter Karl, Moch, Holger, Fankhauser, Christian, Beyer, Jörg   +6 more
core   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Germ cell origin of testicular carcinoid tumors.

, 2008
PURPOSE: Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived from the embryonic gut. These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown.
Cheng L., Rank J. P., Maclennan G. T., Baldridge L. A., Zhang S., Lopez Beltran A., Abbosh P. H., MONTIRONI, RODOLFO   +7 more
core   +1 more source

Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec, Ondrej Simonik, Zuzana Kratka, Lukas Ded, Jana Vondrakova, Maryam Qasemi, Barbora Bryndova, Michala Krejci, Daniela Spevakova, Vishma Pratap Sur, Radomir Kren, Tomas Hradec, Pavel Skrobanek, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Pavla Postlerova, Katerina Komrskova   +18 more
wiley   +1 more source

testicular germ cell tumor

, 2023
Supplementary Table S1: The list of 1,793 immune-related genes (IRGs) was collected from the IMMPORT database. Supplementary Table S2: The progression-free interval (PFI) data of TCGT. Supplementary Table S3: The list of highly amplified, over-expressed, and frequently mutated genes, 203 overlapping genes were identified as potential candidate TGCT ...
openaire   +2 more sources

In Situ Expression of miR‐371a‐3p and miR‐373‐3p in Testicular Germ Cell Tumours and Detection in Serum

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCTs) are the most common type of tumour diagnosed in young men, and reliable non‐invasive biomarkers are crucial for clinical management. MicroRNAs (miRNAs) from the miR‐371–373 cluster have recently been identified as novel and more sensitive serum biomarkers than the conventional protein‐based ...
Nina Mørup, Merve Tatli, Thomas Wagner, Helle Margit Albrechtsen, Gülizar Saritas, Gedske Daugaard, Sofia B. Winge, Kristian Almstrup   +7 more
wiley   +1 more source