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To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm [PDF]

International Journal of Molecular Sciences, 2021
In the human embryo, the genetic program that orchestrates germ cell specification involves the activation of epigenetic and transcriptional mechanisms that make the germline a unique cell population continuously poised between germness and pluripotency.
Francesca Gioia Klinger, Massimo De Felici, Carmela Rita Balistreri   +2 more
exaly   +8 more sources

Intracranial germ cell tumor

Journal of the Belgian Society of Radiology, 2010
Germ cell tumours represent about 3 to 8% of pediatric brain tumours. Occurrence of diabetes insipidus is common in the case of suprasellar germ cell tumors.
J Kreutz, L Rausin, E Weerts, M Tebache, J Born, C Hoyoux   +5 more
doaj   +5 more sources

Extragonadal Primary Mixed Germ Cell Tumor of the Stomach

Journal of Indian Association of Pediatric Surgeons
Germ cell tumors (GCT) are most commonly observed in the gonads. Extragonadal GCTs (EGCT) are uncommon and are considered metastatic or primary tumors. Histologically and immunophenotypically, EGCTs resemble gonadal GCT.
Basharat Mubeen, Roopa Rachel Paulose, Anoop Koshy, Mohan K Abraham, Anju Farsana, Keechilat Pavithran   +5 more
doaj   +2 more sources

Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study

American Journal of Obstetrics and Gynecology, 2018
BACKGROUND: Malignant ovarian germ cell tumors usually occur in young women. Until the 1970s, before establishment of systemic chemotherapy, malignant ovarian germ cell tumors had a very poor prognosis.
Masato Yoshihara, Nobuhisa Yoshikawa, Kimihiro Nishino   +2 more
exaly   +2 more sources

A case report of recurrent testicular germ cell tumor in a patient with a history of primary pulmonary germ cell tumor and a review of the literature

Frontiers in Oncology
BackgroundCompared to testicular germ cell tumors, the incidence of extragonadal germ cell tumors (EGCTs) is relatively low. While the lungs are a common site for metastasis of malignant germ cell tumors, primary pulmonary germ cell tumors are extremely ...
Jian Tan, Jian Tan, Jinfeng Wu, Jinfeng Wu, Runqiang Yuan, Wei Li, Linfeng Li, Hongxing Huang, Hongxing Huang, Yangbai Lu   +9 more
doaj   +3 more sources

Spermatocytic tumor – case report [PDF]

Liječnički vjesnik, 2021
According to the newest WHO classification tumors of the testis are divided into germ cell tumors derived from germ cell neoplasia in situ, germ cell tumors unrelated to germ cell neoplasia in situ, sex cord-stromal tumors, tumors containing both germ ...
Tonći Vodopić, Kristina Vnuk, Goran Štimac, Miroslav Tomić, Božo Krušlin, Monika Ulamec   +5 more
doaj   +1 more source

A massive retroperitoneal mature teratoma from a “burned-out” testicular teratoma and seminoma

Radiology Case Reports, 2022
Germ cell tumors are the most common nonhematologic malignancy of young men which often present with metastasis to the retroperitoneum, however a primary retroperitoneal mass should also be considered. The case presented herein reports a 42-year-old male
William L. Valentino, MD, MS, Kristina Cendrowski, MD, Veena Mandava, MD, Justin Wei, MD   +3 more
doaj   +1 more source

Gene mutation landscape of a rare patient with acute megakaryoblastic leukemia after treatment of intracranial germ cell tumor

Frontiers in Oncology, 2023
IntroductionIt was first reported that germ cell tumor patients suffer from hematologic malignancies 37 years ago. Since then, the number of relevant reports has increased each year, with most cases being mediastinal germ cell tumor.
Li-Xin Wang, Li-Xin Wang, Wei-Jie Liao, Yu-Hua Jiang, Chao Chen, Wang-Sheng Lu, Feng Yin, Hao-Yong Ning   +7 more
doaj   +1 more source

Surgical treatment of metastatic germ cell cancer

Asian Journal of Urology, 2021
Among young men between the ages of 15 and 40 years, germ cell cancer is the most common solid tumor [1]. The worldwide incidence of germ cell cancer is 70 000 cases.
Andreas Hiester, Peter Albers
doaj   +1 more source

Extra-gonadal germ cell tumor

Journal of Pediatric Surgery Case Reports, 2020
This is a case report of a two years old girl that presented to us with an abdominal mass diagnosed on biopsy as Yolk sac tumor with elevated with Alpha fetoprotein.
A. ElRifai, S. Akel
doaj   +1 more source