Results 101 to 110 of about 5,359,290 (244)
Andrology, EarlyView.ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus +6 more
wiley +1 more source
A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics
Andrology, EarlyView.ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis +3 more
wiley +1 more source
Maternal risk factors and testicular cancer in the offspring : A nested case-control study [PDF]
, 2009 Väitöskirja, liitteenä alkuperäisartikkelit (verkkoversiossa ei alkuperäisartikkeleita)ei tietoa saavutettavuudesta unknown ...
Holl, Katsiaryna
core
Abstract 3703: A genomic characterization of testicular germ cell tumor immune microenvironment
, 2017 Testicular germ cell tumors (TGCT) are a histologically diverse set of tumors and the most common cancer type in young men. As part of the TCGA effort, we analyzed tumors from 133 patients including 4 patients with asynchronous double primary TGCTs (137 ...
Benjamin Vincent +4 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background Testicular cancer (TC) is the most common malignancy amongst adolescents and young adults (AYAs) aged 15–39 years assigned male at birth. Survivors often experience late effects of treatment and report unmet supportive care needs.
Mohamad M. Saab +30 more
wiley +1 more source
On the Origin of Testicular Germ Cell Tumors: From Gonocytes to Testicular Cancer
Frontiers in Endocrinology, 2019 Human primordial germ cells (PGCs) have been described in the yolk sac wall around the beginning of the third week. From week 4 to 5, they migrate under control of SCF/c-KIT signaling pathway to the genital ridge, where they become gonocytes.
Tiziano Baroni +6 more
doaj +1 more source
Neoplastic Risk in Patients With Klinefelter Syndrome
Andrology, EarlyView.ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani +4 more
wiley +1 more source
The human germ cell lineage: pluripotency, tumourigenesis and proliferation
, 2008 EThOS - Electronic Theses Online ServiceGBUnited ...
Perrett, Rebecca Mary
core +2 more sources
Andrology, EarlyView.ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova +6 more
wiley +1 more source
Neoangiogenesis in the dynamics of testicular seminoma progression
Journal of Education, Health and Sport, 2019 Testicular germ cell tumors (TGCT) is a group of neoplasms which develop from the germ cell epithelium and account 94-96% of all testicular tumors. Seminoma is the most common testicular germ cell neoplasm and accounts for about 50% of all TGCT.There is ...
S. M. Potapov +2 more
doaj +1 more source