Results 141 to 150 of about 70,701 (334)

Critical Function of PRDM2 in the Neoplastic Growth of Testicular Germ Cell Tumors

Biology, 2016
Testicular germ cell tumors (TGCTs) derive from primordial germ cells. Their maturation is blocked at different stages, reflecting histological tumor subtypes.
E. di Zazzo, C. Porcile, S. Bartollino, B. Moncharmont   +3 more
semanticscholar   +1 more source

Simplified Molecular International Prognostic Index as an eligibility criterion for clinical trials: Analysis of the Turkish Lymphoma Study Group's large B‐cell lymphoma cohort

British Journal of Haematology, EarlyView.
The international prognostic index (IPI)‐driven trial inclusion criteria may have contributed to the failure of some of the first‐line trials in large B‐cell lymphoma (LBCL). GLA and LYSA collaborated to improve prognostic stratification in LBCL by analyzing data from trial cohorts and proposed the smIPI.
Umut Yılmaz, Esra Terzi Demirsoy, Fatma Keklik Karadağ, Uğur Hatipoğlu, Meral Uluköylü Mengüç, Ebru Pekgüç, Taner Tan, Eda Nuhoğlu Kantarcı, Metban Mastanzade, Ali Durdu, Merve Apaydın Kayer, Murat Özbalak, Tuğrul Elverdi, Asu Fergün Yılmaz, Deniz Gören, Tayfur Toptaş, Turgay Ulaş, Özgür Mehtap, Mehmet Sinan Dal, Olga Meltem Akay, Muhlis Cem Ar, Güray Saydam, Fevzi Altuntaş, Elif Birtaş Ateşoğlu, Burhan Ferhanoğlu   +24 more
wiley   +1 more source

Neoangiogenesis in the dynamics of testicular seminoma progression

Journal of Education, Health and Sport, 2019
Testicular germ cell tumors (TGCT) is a group of neoplasms which develop from the germ cell epithelium and account 94-96% of all testicular tumors. Seminoma is the most common testicular germ cell neoplasm and accounts for about 50% of all TGCT.There is ...
S. M. Potapov, O. M. Pliten, N. I. Horhol   +2 more
doaj   +1 more source

Testicular cancer and cryptorchidism [PDF]

, 2013
The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by insulin-like 3 peptide and steroid hormones produced in testicular Leydig cells, as well as by ...
Agoulnik, Alexander I., Ferguson, Lydia
core   +2 more sources

Sentinel lymph node staging in urological cancer surgery: advances in imaging, intra‐operative detection and translational research

BJU International, EarlyView.
Objectives To review the clinical utility, outcome and possible future applications of sentinel lymph node biopsy (SLNB) in penile cancer (PeC), bladder cancer (BCa), prostate cancer (PCa), testicular cancer (TCa) and renal cell carcinoma (RCC), focusing in particular on current SLNB standards and exploring advancements in imaging agents, intra ...
Erik J. van Gennep, Gijs H. KleinJan, Teele Kuusk, Rick W.A. Verdijk, Esther M.K. Wit, Bas W.G. van Rhijn, Axel Bex, Laura S. Mertens   +7 more
wiley   +1 more source

Metastatic Testicular Germ Cell Tumor or a Chemoresponsive Liver Hemangioma? [PDF]

, 2012
Testicular germ cell tumors are the most common solid organ malignancy in young adult men. The presence of non-pulmonary visceral metastasis is an independent factor that places such patients into the higher risk group.
Esteves, D., Ferreira, J., Magalhães, M., Marques, F.   +3 more
core  

Frequent PD-L1 expression in testicular germ cell tumors

British Journal of Cancer, 2015
Background:Many testicular germ cell cancers are curable despite metastatic disease, but about 10–15% of patients fail cisplatin-based first-line treatment. Immunotherapy is considered as additional treatment approach for these patients.
C. Fankhauser, A. Curioni-Fontecedro, V. Allmann, Jörg Beyer, Verena Tischler, T. Sulser, Holger Moch, Peter K. Bode   +7 more
semanticscholar   +1 more source

Nuclear destabilisation – a possible genesis of cancer?

Biological Reviews, EarlyView.
ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal   +4 more
wiley   +1 more source

Epigenetically‐Upregulated CD98 Shed Light on the Precancerous Diagnosis and Prognosis Prediction of Esophageal Cancer

Cancer Science, EarlyView.
This study confirmed that hypomethylation‐induced upregulation of CD98 promoted ESCC cell proliferation by regulating the cell cycle and was correlated with poorer overall survival of ESCC patients. Combined panels of immunohistochemistry (CD98 and P53) are recommended for accurate diagnosis of esophageal precancerous lesions.
Xue Zhang, Mengfei Sun, Na Li, Jie Yu, Wenjie Wang, Ju Yang, Hongyan Wu, Linyue Zhao, Huakun Zhang, Lan Yang, Feng Li, Qi Sun, Yunzhao Chen, Xiaobin Cui   +13 more
wiley   +1 more source

Role of microRNAs in mammalian spermatogenesis and testicular germ cell tumors.

Reproduction, 2015
microRNAs (miRNAs) are a class of small endogenous RNAs, 19-25 nucleotides in size, which play a role in the regulation of gene expression at transcriptional and post-transcriptional levels.
Li Wang, Chen Xu
semanticscholar   +1 more source