Results 191 to 200 of about 8,362,741 (232)

The Need for a Global Registry for Charting the Natural History of Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Although Klinefelter Syndrome (KS) represents the most common sex chromosome aneuploidy, several gaps in knowledge persist regarding optimal management of individuals with this condition. Individuals with KS can have a diverse phenotype including endocrine, neurodevelopmental, and cardiovascular manifestations.
Malika Alimussina, Joseph McElvaney, Corinna Grasemann, Jillian Bryce, Lise Aksglaede, Claudia Boettcher, Lexi Breen, Francesco Carlomagno, Sabine Hannema, Andrea M. Isidori, Inas Mazen, Anna Nordenstrom, S. Faisal Ahmed, Angela K. Lucas‐Herald   +13 more
wiley   +1 more source

The Influence of Suture Type on Postoperative Outcomes in Minimally Invasive Vasectomy

Andrology, EarlyView.
ABSTRACT Objective This study compares vasectomy outcomes between Chromic Gut and Monocryl sutures used for fascial interposition in a large cohort of patients undergoing minimally invasive vasectomy. Current guidelines do not recommend a specific suture material for fascial interposition; therefore, this study aims to evaluate two commonly used ...
Casey Norton, Daniel R. Turin, Bowen Yao, Logan Hubbard, G. Charles Ostermeier, Joshua Bodie   +5 more
wiley   +1 more source

Differential Sperm DNA Methylation Profiles in Healthy Men With High Versus Low Adherence to the Mediterranean Diet in the Led‐Fertyl Study

Andrology, EarlyView.
ABSTRACT Background Diet is known to play an essential role not only in sperm quality but also in offspring health, likely mediated through the sperm epigenome. Moreover, one of the main components of the Mediterranean diet (MedDiet) (i.e., nuts) have shown to impact sperm DNA methylation patterns.
Rashmi Agarwal, Nancy Babio, Estefanía Davila‐Cordova, María Fernández de la Puente, Cristina Valle‐Hita, Carles Arribas, Manel Esteller, Aleix Noguera‐Castells, Raquel Pluvinet, Jordi Salas‐Salvadó, Albert Salas‐Huetos   +10 more
wiley   +1 more source

Androgens Modulate Tumor–Immune Interactions in Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The majority of testicular germ cell tumors (TGCT) are derived from the germ cell neoplasia in situ and arise after puberty in the local presence of high levels of testosterone. The seminoma subtype features a rich inflammatory infiltrate which impacts tumor progression but the role of testosterone in shaping tumor–immune ...
Ida Hamann, Lucas Klaus, Patrick Fruth, Alexander Fichtner, Tobias J. Legler, Holger M. Reichardt, Fabian A. Gayer   +6 more
wiley   +1 more source

Larger Testicular Volume Is Independently Associated with Favorable Indices of Lung Function. [PDF]

Tuberc Respir Dis (Seoul), 2017
Kim TB, Park IN.
europepmc   +1 more source

Cryopreservation Disrupts TRIM21‐Mediated AKAP3 Ubiquitination and Triggers Stress Granule Formation in Human Sperm

Andrology, EarlyView.
ABSTRACT Background Sperm cryopreservation causes cryodamage, but the roles of posttranslational modifications (PTMs) and stress granules (SGs) in this process remain unclear. Objectives To investigate the molecular mechanism of cryodamage via the TRIM21–AKAP3 axis, PTMs, and SGs.
Yan Wang, Huizhong Xu, Wenhong Lu, Yinghao Wang, Jin Ma, Chengyao Ma, Xiangming Yan, Longlong Fu, Haitao Lv, Ying Liu   +9 more
wiley   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Higher LSD1 in Non‐Seminomatous Germ Cell Tumors and LSD1 Inhibition by NCL1 Suppresses Embryonal Carcinoma Growth

Cancer Science, EarlyView.
LSD1 expression was higher in non‐seminomatous than in seminomatous testicular germ cell tumor components. In embryonal carcinoma models, selective LSD1 inhibition by NCL1 induced epigenetic and apoptotic responses, reduced viability including in cisplatin‐adapted cells, and suppressed early xenograft outgrowth, supporting LSD1 as a potential ...
Nobuhiko Shimizu, Toshiki Etani, Taku Naiki, Aya Naiki‐Ito, Yosuke Sugiyama, Takashi Nagai, Akihiro Murakami, Hiroyuki Kato, Toshiharu Morikawa, Maria Aoki, Masakazu Gonda, Hiroko Suzuki, Yohei Tsubouchi, Daiki Ishikawa, Takayoshi Suzuki, Satoru Takahashi, Takahiro Yasui   +16 more
wiley   +1 more source

Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome

Clinical Endocrinology, EarlyView.
ABSTRACT Context Klinefelter syndrome (KS), defined by a 47, XXY karyotype, is commonly associated with progressive testicular failure. The precise timing of Sertoli and Leydig cell dysfunction during puberty remains unclear. Objective To determine the onset and progression of testicular insufficiency during puberty in KS, and to assess whether ...
Tredez Axelle, Christine Lefevre, Simon Boussion, Cindy Colson, Iva Gueorguieva, Francois Marcelli, Anne Laure Barbotin, Pascal Pigny, Hamza Benderradji, Clara Leroy   +9 more
wiley   +1 more source