Results 201 to 210 of about 8,362,741 (232)

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Testosterone Replacement Therapy in Adolescents and Young Adults With Prader‐Willi Syndrome: Efficacy and Effects on Behaviour

Clinical Endocrinology, EarlyView.
ABSTRACT Context Hypogonadism in Prader‐Willi syndrome (PWS) is associated with decreased bone mineral density (BMD) in male adolescents and adults. Testosterone Replacement Therapy (TRT) improves BMD and sexual maturation, but TRT could aggravate pre‐existing challenging behaviour in male patients with PWS.
Wiebe R. Flamman, Demi J. Trueba‐Timmermans, Lionne N. Grootjen, Laura C. G. de Graaff, Joyce M. Geelen, Janielle A. E. M. van der Velden, Edmond H. H. M. Rings, Anita C. S. Hokken‐Koelega, Gerthe F. Kerkhof   +8 more
wiley   +1 more source

Multisystem developmental abnormalities and insulin resistance in ADTKD‐HNF1B with the p.E105K variant: A clinical conundrum

Diabetic Medicine, EarlyView.
Abstract Aims HNF1B variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD‐HNF1B), but the phenotypic spectrum of variants of uncertain significance (VUS) remains incompletely defined. We aimed to characterise the multisystem phenotype associated with the HNF1B p.E105K variant and to examine the mechanism underlying insulin ...
YunZe Wang, KangChun Xu, PengFei Liu, Bin Wang, Yan Yang, ShanZhai Wei   +5 more
wiley   +1 more source

Weight Regain After Incretin Treatment: The Lean Mass Deficit Hypothesis and a Role for Testosterone Combination Therapy in Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1RA and triple (GIP)/GLP‐1RA/glucagon agonists achieve placebo‐subtracted weight loss of 15% to 22%. Their long‐term value depends on how well the weight loss is maintained and on the composition of weight loss, not only
Michael Zitzmann, Zsolt Bosnyak, Richard Jones, Monica Caliber   +3 more
wiley   +1 more source

Testicular torsion in foals and stallions

Equine Veterinary Education, EarlyView.
Summary Testicular torsion is a rare condition in horses characterised by a change in the position of the testis due to the testicular mesentery twisting around its own axis; it can occur both when the testis is still in the abdominal cavity and when it has descended into the scrotum.
C. P. Bartmann
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Crystal structure of human NIF3‐like protein reveals dynamic hexameric assembly with a single divalent metal binding site

The FEBS Journal, EarlyView.
We present the first crystal structures of human NIF3, revealing a dynamic, hexameric ring with a central cavity regulated by flexible insertion domains. Crucially, human NIF3 features a mononuclear zinc‐binding site, marking a distinct evolutionary departure from the dinuclear centers of bacterial homologs.
Elżbieta Wątor‐Wilk, Krzysztof Żak, Piotr Wilk, Paweł Kochanowski, Agnieszka Maślanka, Łukasz Skalniak, Przemysław Grudnik   +6 more
wiley   +1 more source

Predictive utility of computed tomography‐derived renal parenchymal volume for long‐term postoperative renal function in cats with hydronephrosis

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate the utility of preoperative feline renal parenchymal volume derived from computed tomography in predicting the serum creatinine concentration during the long‐term postoperative period. Materials and Methods In this retrospective clinical study, we included 13 client‐owned cats with normal kidneys and 24 cats with hydronephrosis ...
T. Nagumo, Y. Hoshino, S. Kobayashi, R. Fujiwara, M. Yamasaki, K. Nakata, M. Katayama   +6 more
wiley   +1 more source

Clinical value of shear wave elastography (SWE) combined with superb microvascular imaging (SMI) for the evaluation of semen abnormalities. [PDF]

Am J Transl Res
Chen H, Huang J, Li W, Chen H, Peng J, Zeng C.   +5 more
europepmc   +1 more source

Analysis of the Osmolarity of the Liquid Fraction of Squirrel Monkey's Semen (Saimiri collinsi Osgood, 1916) in Fattening and Non-Fattening Conditions. [PDF]

J Med Primatol
Leão DL, Sampaio WV, Soares ARB, Oliveira KG, Dos Reis AN, Imbeloni AA, de Queiroz HL, Domingues SFS.   +7 more
europepmc   +1 more source