Results 61 to 70 of about 8,362,741 (232)

Role of testicular size as a parameter for predicting infertility in Indian males

Journal of Human Reproductive Sciences, 2020
Context (Background): While the semen analysis appears to be the cornerstone in the evaluation of male fertility, the testicular size is a cheap, easy, and convenient to measure yet an ignored parameter for predicting the same.
Amit Bellurkar, Sujata Patwardhan, Bhushan Patil, Ajay Kanbur, Hitesh Jain, Rishikesh Velhal   +5 more
doaj   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Accuracy of Prader orchidometer in measuring testicular volume [PDF]

, 2013
Background: Seminiferous tubules comprise 80‑90% of testicular mass. Thus, the testicular volume is believed to be an index of spermatogenesis. Therefore, accurate testicular volume is one way to assess testicular function.Objective: To determine the ...
Mbaeri, TU, Nwofor, AM, Mbonu, OO, Orakwe, JC, Oranusi, KC   +4 more
core   +1 more source

Ultrasonic testicular size of 24,440 adult Vietnamese men and the correlation with age and hormonal profiles

, 2021
Testicular size is an important parameter to investigate male reproductive and sexual functions. However, diagnosis and treatments are hindered by the lack of country-specific standard values for testicular volume.
Doan Tien, Luu, Nguyen Hoai, Bac, Hoang, Long, Tran, Duc, Nguyen Cao, Thang, Sansone, Andrea, Jannini, Emmanuele A, Luu Doan Tien, Emmanuele A. Jannini, Long Hoang, Thang Nguyen Cao, Bac Nguyen Hoai, Duc Tran, Andrea Sansone   +13 more
core   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2

Annals of Human Biology, 2023
Background The Bergen Growth Study 2 (BGS2) aims to characterise somatic and endocrine changes in healthy Norwegian children using a novel methodology.
Petur B. Juliusson, Ingvild S. Bruserud, Ninnie Helen Bakken Oehme, Andre Madsen, Ingvild H. Forthun, Melissa Balthasar, Karen Rosendahl, Kristin Viste, Astanand Jugessur, Lawrence M. Schell, Robert Bjerknes, Mathieu Roelants   +11 more
doaj   +1 more source

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

Advanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin, Chaojie Lai, Qingyan Zhou, Ruilin Wang, Yiping Tong, Wentao Chen, Nikola Rabrenovic, Tingyu Zhang, Xinrong Ren, Chengchen Huang, Jiawen Chen, Ran Li, Luyang Yu, Massimiliano Mazzone, Wenbin Zhang, Guosheng Fu, Min Shang   +16 more
wiley   +1 more source

A cross-sectional study of cryptorchidism in children: testicular volume and hormonal function at 18 years of age

International Brazilian Journal of Urology, 2015
Purpose To evaluate the relationship between unilateral or bilateral criptorchidism, patient age, primary location of the gonad and modality of treatment with testicular volume and hormonal status at 18 years in patients diagnosed and treated for ...
R. Varela-Cives, R. Méndez-Gallart, E. Estevez-Martínez, P. Rodríguez-Barca, A. Bautista-Casasnovas, M. Pombo-Arias, R. Tojo-Sierra   +6 more
doaj   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source