Results 41 to 50 of about 4,147,366 (254)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Research on Test Method of Active Medical Device Preset Service Life Evaluation
Zhongguo yiliao qixie zazhiWhen applying for registration of an active medical device, it is necessary to submit research and verification data regarding the device's service life.
Fei HE, Weiming WANG
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Zhongguo yiliao qixie zazhiThis study aims to evaluate the application of flower petal-structured electrodes in pulsed field ablation (PFA) technology, with a particular focus on their performance in myocardial tissue ablation. Through a combination of simulation techniques and in
Lingfeng LU, Huiming CHEN
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Zhongguo yiliao qixie zazhiWith the widespread application of medical device software in clinical diagnosis and treatment, the accuracy and reliability of graphics measurement functions, which are core modules of medical device software, directly impact the quality of medical ...
Zhongsheng LIU, Yinjie LI
doaj +1 more source
A case study: Design and manufacture of an eccentric spring fatigue testing device
, 2018 Fatigue is one of the most significant causes of spring damage. Since fatigue tests play a crucial role in predicting the lifespan of springs, many special test device and test techniques have been described in the literature.
Çavdar, Kadir
core +1 more source
Radiated Immunity Testing of a Device with an External Wire: Repeatibility of Reverberation Chamber Results and Correlation with Anechoic Chamber Results [PDF]
, 2003 We present the experimental radiated immunity results of an electronic device with an external wire obtained in reverberation and anechoic chambers. Repeatability and reproducibility of reverberation chamber measurements are investigated by repeating the
Berat, V. +6 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
An Adaptive LSTM Method for Parameter Calibration of Medical Robotic Arms
Zhongguo yiliao qixie zazhiMedical robotic arm often encounters multi-source and nonlinear errors during the calibration process, making it difficult for traditional mathematical modeling methods to fully characterize system error features, thereby limiting further improvement in ...
Wei HONG, Lukai JIN
doaj +1 more source