Results 51 to 60 of about 483,812 (310)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Simulation Study of Myocardial Tissue Ablation Effects Using Flower Petal-Structured Electrodes in Pulsed Ablation

open access: yesZhongguo yiliao qixie zazhi
This study aims to evaluate the application of flower petal-structured electrodes in pulsed field ablation (PFA) technology, with a particular focus on their performance in myocardial tissue ablation. Through a combination of simulation techniques and in
Lingfeng LU, Huiming CHEN
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Research on Standardized Testing Processes and Methods of Graphics Measurement Functions of Medical Device Software

open access: yesZhongguo yiliao qixie zazhi
With the widespread application of medical device software in clinical diagnosis and treatment, the accuracy and reliability of graphics measurement functions, which are core modules of medical device software, directly impact the quality of medical ...
Zhongsheng LIU, Yinjie LI
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Dynamic Brinell hardness testing

open access: yes, 2021
The following thesis embodies a limited literary perusal of the subject and the results of an investigation into the reliability and adaptability of a portable hardness testing device, to commercial testing.
Lyon, G.M., Murray, W. M.
core  

Research on Test Method of Active Medical Device Preset Service Life Evaluation

open access: yesZhongguo yiliao qixie zazhi
When applying for registration of an active medical device, it is necessary to submit research and verification data regarding the device's service life.
Fei HE, Weiming WANG
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Testing Device for Metro Vehicle SIV Controller

open access: yes, 2013
A testing device for metro vehicle SIV controller was developed in this paper. The general situation of testing device for SIV controller was firstly introduced, then hardware design of testing device was analyzed emphatically, and software design of ...
TAN Li-hong   +3 more
core   +1 more source

Biaxial Testing Machine: Development and Evaluation

open access: yes, 2020
Biaxial mechanical testing gained increased importance for characterization of materials that present anisotropic behavior and/or different responses when subjected to tensile and compression loadings.
Alfredo B. de Morais   +3 more
core   +1 more source

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