Results 71 to 80 of about 4,147,366 (254)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Role of Establishment of Allowable Limits for Leachable Substances in Safety Evaluation of Medical Devices

Zhongguo yiliao qixie zazhi
The objective of inspection, testing and supervision of medical devices is to ensure the effectiveness and safety of medical devices in use. Leachables are substances that are leached from medical devices or materials during their clinical use ...
Fangming XU
doaj   +1 more source

Recent advancements in Lorentz force eddy current testing [PDF]

, 2016
Lorentz Force Eddy Current Testing (LET) is a non-destructive testing technique based on induced eddy currents due to relative motion between a permanent magnet and a conductive, non-ferromagnetic device under test which has been recently introduced. The
Weise, Konstantin, Ziolkowski, Marek, Schmidt, Reinhard, Gorges, Stephan, Carlstedt, Matthias, Brauer, Hartmut   +5 more
core  

Accelerated testing of multi-walled CNT composite electrical contacts for MEMS switches

, 2014
The use of gold-coated multi-walled carbon nanotube (Au/MWCNT) bilayer composite surfaces has been discussed in previous work as a method for improving the reliability of switch contacts [1, 2].
Lewis, Adam P., Suan Hui Pu, Liudi Jiang, Jiang, Liudi, John W. McBride, McBride, John W., Pu, Suan-Hui, Adam P. Lewis   +7 more
core   +1 more source

The impact of cognitive testing on the welfare of group housed primates [PDF]

, 2013
Providing cognitive challenges to zoo-housed animals may provide enriching effects and subsequently enhance their welfare. Primates may benefit most from such challenges as they often face complex problems in their natural environment and can be observed
Whitehouse, J, Waller, BM, Powell, Lauren E., Jérôme Micheletta, Lauren E. Powell, Powell, LE, Micheletta, J, Bridget M. Waller, Celia Bordier, Whitehouse, Jamie, Bordier, Celia, Bordier, C, Micheletta, Jerome, Jamie Whitehouse, Lauren E Powell, Bridget M Waller, Waller, Bridget M.   +16 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Analysis of Engine Knock Sensor

Communications, 2018
The paper deals with design of a simple device for the detection of this disorder. In the beginning of the paper the effect of the undesirable detonation combustion in internal combustion engines is described.
Daniel Korenciak, Miroslav Gutten, Juraj Adamec, Adam Glowacz, Adam Cichy   +4 more
doaj   +1 more source

A self-rectifying HfO x-based unipolar RRAM with Nisi electrode

, 2012
10.1109/LED.2011.2181971IEEE Electron Device Letters334585 ...
Kang, J.F., Zhu, W. G., Yeo, Y.C., Tran, Xuan Anh, Liu, W.J., Gao, B., Nguyen, B. Y., Kang, J. F., Gao, Bin, Yeo, Y. C., Wang, Z.R., Tran, X.A., Yu, H.Y., Tran, X. A., Yu, H. Y., Nguyen, B.Y., Liu, W. J., Wang, Z. R., Li, M.F., Li, M. F., Yu, Hongyu, Zhu, W.G., Fang, Z.   +22 more
core   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source