Results 71 to 80 of about 483,812 (310)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Research Progress of 3D-Printed Polyetheretherketone in Implantable Medical Devices
Zhongguo yiliao qixie zazhiPolyetheretherketone (PEEK) has emerged as a thermoplastic material of choice in the realm of implantable medical devices, owing to its high biocompatibility and exceptional mechanical strength.
Shangda ZHANG
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A device for testing tractors on fields
, 2014 A new dynamometer vehicle was developed by the Hungarian Institute of Agricultural Engineering (MGI) to determine the traction performances of agricultural tractors on soft soil (fields) and on hard surfaces.
Szente, Márk +2 more
core
Development of a Simplified Dynamic Testing Device for Turfed Sports Surfaces [PDF]
, 2011 The response of natural turf surfaces to loading changes with the force and loading rate applied. Quantification of surface behaviour to athlete loading is complicated by the lack of devices that replicate forces, stresses and loading rates of ...
D I Bartlett +7 more
core +1 more source
Zhongguo yiliao qixie zazhiThe objective of inspection, testing and supervision of medical devices is to ensure the effectiveness and safety of medical devices in use. Leachables are substances that are leached from medical devices or materials during their clinical use ...
Fangming XU
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Automatic volume measuring device for testing of dry soils. Martina
, 1997 Automatic volume measuring device for testing of dry soils ...
FIORAVANTE, Vincenzo, CAPOFERRI R.
core
Research on Electromagnetic Compatibility Immunity Testing Methods for Proton Therapy System
Zhongguo yiliao qixie zazhiThe proton therapy system has significant clinical advantages over traditional tumor radiation treatment equipment and is also far more complex in terms of system architecture.
Weiwei LU
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source