Results 81 to 90 of about 483,812 (310)

Analysis of Engine Knock Sensor

open access: yesCommunications, 2018
The paper deals with design of a simple device for the detection of this disorder. In the beginning of the paper the effect of the undesirable detonation combustion in internal combustion engines is described.
Daniel Korenciak   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

User involvement in healthcare technology development and assessment: Structured literature review

open access: yes, 2006
Purpose – Medical device users are one of the principal stakeholders of medical device technologies. User involvement in medical device technology development and assessment is central to meet their needs.
Ian Robinson   +3 more
core   +1 more source

Process of designing robust, dependable, safe and secure software for medical devices: Point of care testing device as a case study [PDF]

open access: yes, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Copyright © 2013 Sivanesan Tulasidas et al. This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of ...
Craw, P   +11 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Development of an Automated Test System for Pacing Performance

open access: yesZhongguo yiliao qixie zazhi
This study presents the design of an automated control system based on LabVIEW development technology, aiming to develop a high-precision and fully automated pacing performance testing system.
Ya CHEN, Yumin FAN, Xiaoqing ZHANG
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Device-independent verification of Einstein-Podolsky-Rosen steering

open access: yes, 2019
Entanglement lies at the heart of quantum mechanics, and has been identified an essential resource for diverse applications in quantum information.
Shuming Cheng (14115726)   +9 more
core   +1 more source

Characterization of external defibrillator output and its impact on defibrillation protection of medical equipment

open access: yesResuscitation Plus
Background: Defibrillators constitute a critical component of emergency care for ventricular fibrillation and pulseless ventricular tachycardia. Advances in defibrillation technology point to the potential need for reassessing current requirements for ...
Dian Zhang, Jin Deng, Yong Yin
doaj   +1 more source

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