Results 21 to 30 of about 256,296 (370)
Life, 2021 The sex chromosomes play central roles in determining the sex of almost all of the multicellular organisms. It is well known that meiosis in mammalian spermatogenesis produces ~50% Y- and ~50% X-chromosome-bearing sperm, a 1:1 ratio. Here we first reveal
Chengqing Hu +4 more
doaj +1 more source
bioRxiv, 2019 The testis is a peculiar tissue in many respects. It shows patterns of rapid gene evolution and provides a hotspot for the origination of genetic novelties such as de novo genes, duplications and mutations.
Evan Witt +3 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 542-549, December 2022., 2022 Schematic diagram showing RHAU can bind and unwind the G4 “knots” to modulate embryonic development and post‐natal organ function. Deficiency of RHAU gives rise to embryonic lethality, impaired organogenesis and organ dysfunction. RHAU modulates Nkx2‐5 mRNA and Yap1 mRNA at the post‐transcriptional level and facilitates the transcription of c‐Kit and ...
Chensi Yang +5 more
wiley +1 more source
Cancer Testis Antigens and Immunotherapy: Where Do We Stand in the Targeting of PRAME?
Cancers, 2019 PRAME or PReferentially expressed Antigen in Melanoma is a testis-selective cancer testis antigen (CTA) with restricted expression in somatic tissues and re-expression in various cancers.
G. Al-Khadairi, J. Decock
semanticscholar +1 more source
Technology in Cancer Research & Treatment, 2020 Background: Cancer-testis genes can serve as prognostic biomarkers and valuable targets for immunotherapy in multiple tumors because of their restricted expression in testis and cancer.
Yan-Peng Zhang MD +8 more
doaj +1 more source
Clinical Medicine Insights: Reproductive Health, 2019 Young boys undergoing gonadotoxic treatments are at high risk of spermatogonial stem cell (SSC) loss and fertility problems later in life. Stem cell loss can also occur in specific genetic conditions, eg, Klinefelter syndrome (KS).
Aude Braye +2 more
doaj +1 more source
Ile de France IF X Akkaraman AK G 1 Erkek Kuzularının Testis Özelliklerine Ait Katılım Dereceleri
Journal of Agricultural Sciences, 2002 Bu araşt ı rmada, Ile de France IF x Akkaraman AK G İ erkek kuzularda baz ı testis özelliklerine ait kal ı t ı m dereceleri tahmin edilmi ştir. Kesimden önce saptanan testis özelliklerinden sol ve sa ğ testis çap ı , sol ve sa ğ testis uzunluğu,
Gürsel Dellal, Ali Murat Tatar
doaj +1 more source
Biology of Reproduction, 2019 More than 1000 genes are predicted to be predominantly expressed in mouse testis, yet many of them remain unstudied in terms of their roles in spermatogenesis and sperm function and their essentiality in male reproduction.
Yonggang Lu +27 more
semanticscholar +1 more source
The Mammalian Blood-Testis Barrier: Its Biology and Regulation.
Endocrine reviews, 2015 Spermatogenesis is the cellular process by which spermatogonia develop into mature spermatids within seminiferous tubules, the functional unit of the mammalian testis, under the structural and nutritional support of Sertoli cells and the precise ...
D. Mruk, C. Cheng
semanticscholar +1 more source