Results 71 to 80 of about 256,296 (370)

Exploring Brown Dwarf Disks [PDF]

, 2001
We discuss the spectral energy distribution of three very low mass objects in Chamaeleon I for which ground-based spectroscopy and photometry as well as ISO measurements in the mid-infrared are available (Comeron et al. 2000; Persi et al. 2000). One of these stars (Cha Halpha1) is a bona-fide brown dwarf, with mass 0.04-0.05 Msun.
arxiv   +1 more source

Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer

Nature Communications, 2015
Tumours frequently activate genes whose expression is otherwise biased to the testis, collectively known as cancer–testis antigens (CTAs). The extent to which CTA expression represents epiphenomena or confers tumorigenic traits is unknown. In this study,
K. Maxfield, Patrick J. Taus, Kathleen Corcoran, J. Wooten, Jennifer Macion, Yunyun Zhou, Mark D. Borromeo, R. Kollipara, Jingsheng Yan, Yang Xie, Xian-Jin Xie, Angelique W. Whitehurst   +11 more
semanticscholar   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Dysregulation of angiogenesis-specific signalling in adult testis results in xenograft degeneration

Scientific Reports, 2017
Ectopic xenografting of testis is a feasible option for preservation of male fertility and angiogenesis plays a pivotal role in xenograft survival and functionality.
Lalitha Devi, Lavanya Pothana, Sandeep Goel   +2 more
doaj   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

Prodrugs of the Archetypal Dynamin Inhibitor Bis‐T‐22

ChemMedChem, Volume 17, Issue 24, December 16, 2022., 2022
The Bis‐T series of compounds comprise some of the most potent inhibitors of dynamin GTPase activity yet reported, such as Bis‐T‐22 (2). The catechol moieties are believed to limit cell permeability, rendering these compounds largely inactive in cells.
Luke R. Odell, Mark J Robertson, Kelly A Young, Andrew B. McGeachie, Annie Quan, Phillip J. Robinson, Adam McCluskey   +6 more
wiley   +1 more source

Deregulation of sertoli and leydig cells function in patients with klinefelter syndrome as evidenced by testis transcriptome analysis

BMC Genomics, 2015
BackgroundKlinefelter Syndrome (KS) is the most common abnormality of sex chromosomes (47,XXY) and represents the first genetic cause of male infertility.
M. d’Aurora, A. Ferlin, M. Di Nicola, A. Garolla, L. De Toni, S. Franchi, G. Palka, C. Foresta, L. Stuppia, V. Gatta   +9 more
semanticscholar   +1 more source

Genomic Insights into Post‐Domestication Expansion and Selection of Body Size in Ponies

Advanced Science, EarlyView.
The authors’ research delves into the history of ponies by assembling a pony genome and integrating horse genomes. This unveils genetic connections between Asian and European pony breeds. Cis‐regulatory elements of key genes impacting body size are also identified.
Xingzheng Li, Zihao Wang, Min Zhu, Binhu Wang, Shaohua Teng, Jing Yan, Haoyu Wang, Pengxiang Yuan, Shuwei Cao, Xiaolu Qu, Zhen Wang, Kai Zhan, Md. Panir Choudhury, Xintong Yang, Qi Bao, Sang He, Lei Liu, Pengju Zhao, Jicai Jiang, Hai Xiang, Lingzhao Fang, Zhonglin Tang, Yuying Liao, Guoqiang Yi   +23 more
wiley   +1 more source

Spexin in the European sea bass, Dicentrarchus labrax: Characterization, brain distribution, and interaction with Gnrh and Gnih neurons

Journal of Comparative Neurology, Volume 531, Issue 2, Page 314-335, February 2023., 2023
The main objective of this work was to obtain detailed information on the distribution and localization of the spexin (Spx) system in the sea bass brain. To this purpose, we first identified and characterized the spx1 gene and analyzed its expression in the central nervous system (CNS) of the European sea bass by using quantitative Real‐Time Polymerase
José A. Paullada‐Salmerón, Bin Wang, José A. Muñoz‐Cueto   +2 more
wiley   +1 more source

Cancer testis antigens in newly diagnosed and relapse multiple myeloma: prognostic markers and potential targets for immunotherapy

Haematologica, 2011
Background In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not yet been evaluated for a large panel of cancer testis antigens which can be ...
Mark van Duin, Annemiek Broyl, Yvonne de Knegt, Hartmut Goldschmidt, Paul G. Richardson, Wim C. J. Hop, Bronno van der Holt, Debora Joseph-Pietras, George Mulligan, Rachel Neuwirth, Surinder S. Sahota, Pieter Sonneveld   +11 more
doaj   +1 more source