Results 81 to 90 of about 312,372 (339)

Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes

Diabetes Care, 2015
OBJECTIVE One-third of men with type 2 diabetes have hypogonadotropic hypogonadism (HH). We conducted a randomized placebo-controlled trial to evaluate the effect of testosterone replacement on insulin resistance in men with type 2 diabetes and HH ...
S. Dhindsa, H. Ghanim, M. Batra, Nitesh D Kuhadiya, S. Abuaysheh, S. Sandhu, K. Green, A. Makdissi, J. Hejna, A. Chaudhuri, M. Punyanitya, P. Dandona   +11 more
semanticscholar   +1 more source

Testosterone and the brain [PDF]

The Aging Male, 2006
Gender differences in spatial recognition, and age-related declines in cognition and mood, point towards testosterone as an important modulator of cerebral functions. Testosterone appears to activate a distributed cortical network, the ventral processing stream, during spatial cognition tasks, and addition of testosterone improves spatial cognition in ...
openaire   +2 more sources

Self‐Administered Taste Testing Without Water: Normative Data for the 53‐Item Waterless Empirical Taste Test (WETT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background According to the National Health and Nutrition Examination Survey (NHANES), more than 20 million Americans suffer from chronic taste problems. Unfortunately, quantitative testing is rarely performed, self‐reports are inaccurate, and “taste” is often confused with olfaction‐dependent flavors.
Richard L. Doty, Ryan Sharetts, Shima T. Moein   +2 more
wiley   +1 more source

Protective effects of allicin against stanozolol‐induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model

Animal Models and Experimental Medicine, EarlyView.
There are many forms of anabolic steroids, including stanzolo (Winstrol), which are popular for their muscle‐building effects but dangerous to the heart. This present work is aimed at evaluating the pharmacological impact of allacin, a natural attribute obtained from garlic on obstructing cardiac injury in rabbits that received stanzolo.
Mohammed Hayder Asker, Noor AL‐Huda Salah AL‐Zuhairy, Wassan Mhammed Husain, Mustafa Riyadh Abdullah   +3 more
wiley   +1 more source

Extracellular vesicles in mouse testes elevate the level of serum testosterone

Reproductive and Developmental Medicine, 2019
Objective: Testosterone plays an essential role in maintaining spermatogenesis and male fertility, and the primary known source of testosterone is testicular Leydig cells, which are regulated by luteinizing hormone (LH).
Da-Min Yun, Sheng Gao, Yu Lin, Xiao-Long Wu, A-Juan Liang, Fei Sun   +5 more
doaj   +1 more source

Treatment of Men for “Low Testosterone”: A Systematic Review

PLoS ONE, 2016
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of “low testosterone” (low-T) for cardiovascular health, sexual function, muscle weakness or wasting, mood and behavior, and cognition.
Samantha Huo, A. Scialli, Sean C. McGarvey, E. Hill, Buğra Tügertimur, Alycia Hogenmiller, Alessandra I. Hirsch, A. Fugh-Berman   +7 more
semanticscholar   +1 more source

Midlife Steroid‐Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women

Annals of Neurology, EarlyView.
Objective In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later‐life in vivo markers of β‐amyloid (Aβ) and tau deposition in clinically healthy older men. Methods This time‐
Rachel F. Buckley, Matthew Scott, Emer R. McGrath, Gillian Coughlan, Mabel Seto, Saptaparni Ghosh, Heidi I. L. Jacobs, Claudia L. Satizabal, Emma Thibault, Vasan Ramachandran, Joanne M. Murabito, Reisa A. Sperling, Keith A. Johnson, Ravi Jasuja, Shalender Bhasin, Sudha Seshadri, Alexa S. Beiser   +16 more
wiley   +1 more source

Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement.

Journal of Clinical Endocrinology and Metabolism, 2007
OBJECTIVE The objective of the study was to evaluate the current state of clinical assays for total and free testosterone. PARTICIPANTS The five participants were appointed by the Council of The Endocrine Society and charged with attaining the ...
W. Rosner, R. Auchus, R. Azziz, P. Sluss, H. Raff   +4 more
semanticscholar   +1 more source

μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks

Annals of Neurology, EarlyView.
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim, Manyoel Lim, Thiago D. Nascimento, Frank Porreca, Robert A. Koeppe, Nouchine Hadjikhani, Alexandre F. DaSilva   +6 more
wiley   +1 more source

Medication adherence during the run‐in phase of clinical trials: A systematic review of methodological and reporting rigour

British Journal of Clinical Pharmacology, EarlyView.
Aims Trial run‐in phases are sometimes used to select adherent participants as a strategy to enrich trials, but the methods employed lack clear regulatory guidance and there are concerns about the transparency of reporting. This review aims to characterize the methods used for adherence measurement and public reporting of run‐in studies.
Non Davies, Bernard Vrijens, Daniel F. B. Wright, Dyfrig A. Hughes   +3 more
wiley   +1 more source