Results 61 to 70 of about 231,442 (307)

p38 mediates T-2 toxin-induced Leydig cell testosterone synthesis disorder

open access: yesEcotoxicology and Environmental Safety, 2023
T-2 toxin is an unavoidable food and feed contaminant that seriously threatens human and animal health. Exposure to T-2 toxin can cause testosterone synthesis disorder in male animals, but the molecular mechanism is still not completely clear.
Xu Yang   +9 more
doaj   +1 more source

The VCPIP1‐UBE3A Deubiquitination‐Ubiquitination Cascade Contributes to Castration‐Resistant Prostate Cancer Progression

open access: yesAdvanced Science, EarlyView.
VCIPIP1 emerges as a molecular link between protein stability and prostate cancer progression. By deubiquitinating and stabilizing UBE3A, VCIPIP1 promotes p53 degradation and progression to castration‐resistant prostate cancer. Elevated VCIPIP1 expression is associated with shorter castration‐resistant prostate cancer–free survival, highlighting the ...
Fei Lin   +9 more
wiley   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun   +7 more
wiley   +1 more source

Testosterone Levels in Adolescents and Young Men with Type 1 Diabetes and Their Association with Diabetic Nephropathy

open access: yesBiology, 2021
The association between serum testosterone levels and type 1 diabetes (T1D), especially in adolescents and young adults, has not been fully investigated.
Jeongwoo Kang   +8 more
doaj   +1 more source

Endurance sports and testosterone

open access: yes, 2023
reservedIl testosterone, noto ormone steroideo, riveste un ruolo cruciale nelle dinamiche biochimiche e fisiologiche dell’uomo. Il suo impiego esogeno nasce da necessità mediche, in quanto prevalentemente indicato per il trattamento dell’ipogonadismo ...
BARCO, ELIA
core  

Determining the timeline of gonadal and genital differentiation in male and female equine fetuses allows for early detection and intervention in malformations

open access: yesThe Anatomical Record, EarlyView.
Abstract Sexual differentiation in the equine fetus involves coordinated morphogenetic processes that shape both the gonads and the genital ducts. Although the formation of testes and ovaries has been relatively well documented, the temporal dynamics and morphometric patterns of the mesonephric (Wolffian) and paramesonephric (Müllerian) ducts remain ...
Tais Harumi de Castro Sasahara   +4 more
wiley   +1 more source

TESTOSTERONE-DEPENDENT SEXUAL DIMORPHISM IN MOUSE SUBMANDIBULAR GLANDS ASSTUDIED BY LIGHT AND ELECTRON MICROSCOPY.

open access: yes, 1968
TESTOSTERONE-DEPENDENT SEXUAL DIMORPHISM IN MOUSE SUBMANDIBULAR GLANDS ASSTUDIED BY LIGHT AND ELECTRON ...
EDWARD WILLIAM. GRESIK (7985126)
core   +4 more sources

Safety and efficacy of testosterone gel in the treatment of male hypogonadism

open access: yesClinical Interventions in Aging, 2009
Kishore M Lakshman, Shehzad BasariaSection of Endocrinology, Diabetes, and Nutrition. Boston University School of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Transdermal testosterone gels were first introduced in the US in 2000. Since then,
Kishore M Lakshman, Shehzad Basaria
doaj  

Associations of Endogenous Testosterone and Lipid Profiles in Middle-Aged to Older Taiwanese Men

open access: yes, 2012
The relationship between endogenous plasma testosterone and plasma lipids was assessed among 856 Taiwanese men >= 40 years old originally recruited for an epidemiological study of testosterone deficiency syndrome. Blood samples were drawn from fasting n =
JIANN, BANG-PING;HSIEH, JU-TON;LIU, SHIH-PING;WU, HSI-CHIN   +1 more
core   +1 more source

Cortical bone distribution in the human mandibular symphysis: Ontogenic and morphometric approaches in archeological context

open access: yesThe Anatomical Record, EarlyView.
Abstract The human mandibular symphysis concentrates multiaxial loads during function and remodels throughout growth, but the precise mechanisms underlying cortical bone shape during growth remain relatively unexplored. Approaches based solely on thickness or external cortical contours provide only partial insights and do not capture the functional ...
Ana Ribeiro   +3 more
wiley   +1 more source

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