Results 41 to 50 of about 223,762 (305)

Free Testosterone Reflects Metabolic as well as Ovarian Disturbances in Subfertile Oligomenorrheic Women

International Journal of Endocrinology, 2018
Background. Diagnosing polycystic ovary syndrome (PCOS) is based on ovulatory dysfunction, ovarian ultrasound data, and androgen excess. Total testosterone is frequently used to identify androgen excess, but testosterone is mainly bound to sex hormone ...
L. Antonio, S. Pauwels, M. R. Laurent, D. Vanschoubroeck, I. Jans, J. Billen, F. Claessens, B. Decallonne, Diane De Neubourg, P. Vermeersch, D. Vanderschueren   +10 more
doaj   +1 more source

Testosterone, testosterone therapy and prostate cancer

The Aging Male, 2019
With prostate cancer not observed in eunuchs and total androgen suppression by castration an effective first-line treatment for advanced prostate cancer, the dramatic regression seen in tumour symptoms after castration, lead to the theory that high levels of circulating androgens were a risk factor for prostate cancer.
A, Yassin, K, AlRumaihi, R, Alzubaidi, S, Alkadhi, A, Al Ansari   +4 more
openaire   +2 more sources

Testosterone and the Heart [PDF]

Methodist DeBakey Cardiovascular Journal, 2017
Testosterone (T) has a number of important effects on the cardiovascular system. In men, T levels begin to decrease after age 40, and this decrease has been associated with an increase in all-cause mortality and cardiovascular (CV) risk. Low T levels in men may increase their risk of developing coronary artery disease (CAD), metabolic syndrome, and ...
Travis, Goodale, Archana, Sadhu, Steven, Petak, Richard, Robbins   +3 more
openaire   +2 more sources

Serum Testosterone and Cortisol Concentrations After Single-Dose Administration of 100-Mg Transdermal Testosterone in Healthy Men

Frontiers in Pharmacology, 2019
The growing interest in testosterone's effects on men's social behaviors, in particular aggressive, risk-taking, or status maintenance behaviors, is accompanied by a paucity of dose-dependent pharmacokinetic data. Examining the neurophysiological effects
Andrei A. Puiu, Andrei A. Puiu, Sina Radke, Mikhail Votinov, Mikhail Votinov, Ute Habel, Ute Habel, Beate Herpertz-Dahlmann, Bruce Turetsky, Kerstin Konrad, Kerstin Konrad   +10 more
doaj   +1 more source

Testosterone concentrations and prescription patterns of 1% testosterone gel in transgender and gender diverse individuals

Therapeutic Advances in Endocrinology and Metabolism, 2022
Background: Masculinising hormone therapy with testosterone is used to align an individual’s physical characteristics with their gender identity. Standard testosterone doses and formulations recommended for hypogonadal cisgender men are typically ...
Brendan J. Nolan, Sav Zwickl, Alex F. Q. Wong, Peter Locke, Satu Simpson, Ling Li, Jeffrey D. Zajac, Ada S. Cheung   +7 more
doaj   +1 more source

Study protocol to investigate the effects of testosterone therapy as an adjunct to exercise rehabilitation in hypogonadal males with chronic heart failure [PDF]

, 2006
Testosterone deficiency is a common occurrence in men with chronic heart failure (CHF) and may underpin features of advanced disease, including reduced skeletal muscle mass and fatigue.
Mathur, Atish, Zwierska, Irena, Saxton, John, Saxton, John M, Channer, Kevin S, Channer, Kevin   +5 more
core   +1 more source

Fabrication of silastic testosterone enanthate implants to achieve virilizing levels of serum testosterone in swine

MethodsX
The aim of this study was to create a continuous drug delivery system that would yield serum testosterone levels in sexually mature, female pigs consistent with serum testosterone levels of human transgender men.
Nirvana Mahabir, Annie E. Newell-Fugate
doaj   +1 more source

Differential Effects of Neonatal Testosterone Treatment on Aggression in Two Selection Lines of Mice [PDF]

, 1992
Selection lines of mice, artificially selected for aggression based upon the attack latency score (ALS), were used. In order to determine the relative contribution of neonatal testosterone (T) in the development of aggression, we vary the plasma-T level ...
Compaan, Josje C.,, Koolhaas, Jaap M.,, Oortmerssen, Geert A. van, Koolhaas, Jaap M., Bohus, Béla,, van Oortmerssen, Geert A., Ruiter, Anne J.H. de,, Compaan, Josje C., Ruiter, Anne J.H. de, Bohus, Bela, Oortmerssen, Geert A. van,, de Ruiter, Anne J.H.   +11 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Testosterone for schizophrenia

Cochrane Database of Systematic Reviews, 2006
Recently, sex hormones such as estrogens and testosterone or its derivatives have been the focus of interest for treatment of persistent symptoms associated with schizophrenia.To review the effects of dehydroepiandrosterone (DHEA)/testosterone as adjunctive therapy to standard antipsychotic drugs.We searched the Cochrane Schizophrenia Group Trials ...
Elias, Alby, Kumar, Ajit
openaire   +2 more sources