Results 31 to 40 of about 145,336 (169)

Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver

Frontiers in Endocrinology, 2023
Preclinical and clinical studies suggest that hypothyroidism might cause hepatic endocrine and metabolic disturbances with features that mimic deficiencies of testosterone and/or GH.
Leandro Fernández-Pérez, Leandro Fernández-Pérez, Borja Guerra, Borja Guerra, Carlota Recio, Juan José Cabrera-Galván, Irma García, Juan Vladimir De La Rosa, Antonio Castrillo, Antonio Castrillo, Antonio Castrillo, Diego Iglesias-Gato, Mario Díaz   +12 more
doaj   +1 more source

Testosterone increases the virulence traits of uropathogenic Escherichia coli

Frontiers in Microbiology
Uropathogenic Escherichia coli (UPEC) is the most common cause of urinary tract infections (UTIs) in humans. Testosterone negatively impacts UTIs by affecting the immune response, leading to higher susceptibility of chronic cystitis in individuals with ...
Rongrong Wu, Carolina Pettersson, Carolina Pettersson, Isak Demirel   +3 more
doaj   +1 more source

Salivary testosterone levels in preadolescent children

BMC Pediatrics, 2002
Background Saliva reflects the plasma free fraction of testosterone which is biologically active, and available for uptake by tissues. Testosterone concentration in saliva, though differing slightly from the concentration of unbound testosterone in serum,
Dohnányiová Monika, Putz Zdenek, Pastor Karol, Ostatníková Daniela, Mat'ašeje Anna, Hampl Richard   +5 more
doaj   +1 more source

Sustained testosterone suppression: prognostic indicator in advanced hormone sensitive prostate cancer

Frontiers in Endocrinology
ObjectiveWe aimed to investigate the relationship between sustained testosterone suppression and clinical outcomes in advanced hormone-sensitive prostate cancer (aHSPC), which integrates longitudinal testosterone with castration duration to predict tumor
Dongsheng Ma, Dongsheng Ma, Tao Zhuo, Xin Huang, Jianhong Xi   +4 more
doaj   +1 more source

p38 mediates T-2 toxin-induced Leydig cell testosterone synthesis disorder

Ecotoxicology and Environmental Safety, 2023
T-2 toxin is an unavoidable food and feed contaminant that seriously threatens human and animal health. Exposure to T-2 toxin can cause testosterone synthesis disorder in male animals, but the molecular mechanism is still not completely clear.
Xu Yang, Wenxi Song, Kefei Zhang, Youshuang Wang, Fengjuan Chen, Yunhe Chen, Tingyu Huang, Yibao Jiang, Xuebing Wang, Cong Zhang   +9 more
doaj   +1 more source

Safety and efficacy of testosterone gel in the treatment of male hypogonadism

Clinical Interventions in Aging, 2009
Kishore M Lakshman, Shehzad BasariaSection of Endocrinology, Diabetes, and Nutrition. Boston University School of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Transdermal testosterone gels were first introduced in the US in 2000. Since then,
Kishore M Lakshman, Shehzad Basaria
doaj  

TESTOSTERONE CHANGES IN PATIENTS WITH LIVER CIRRHOSIS BEFORE AND AFTER ORTHOTOPIC LIVER TRANSPLANTATION AND ITS CORRELATION WITH MELD

Arquivos de Gastroenterologia, 2014
Context Hypogonadism is a common clinical situation in male patients with liver cirrhosis. Objectives The aim of the present study was to evaluate the effects of orthotopic liver transplantation on testosterone, free testosterone and sex hormone ...
Rodrigo NITSCHE, Júlio Cezar Uili COELHO, Alexandre Coutinho Teixeira de FREITAS, Clementino ZENI NETO, Eduardo MARTINS   +4 more
doaj   +1 more source

Genetic determinants of serum testosterone concentrations in men.

PLoS Genetics, 2011
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity.
Claes Ohlsson, Henri Wallaschofski, Kathryn L Lunetta, Lisette Stolk, John R B Perry, Annemarie Koster, Ann-Kristin Petersen, Joel Eriksson, Terho Lehtimäki, Ilpo T Huhtaniemi, Geoffrey L Hammond, Marcello Maggio, Andrea D Coviello, EMAS Study Group, Luigi Ferrucci, Margit Heier, Albert Hofman, Kate L Holliday, John-Olov Jansson, Mika Kähönen, David Karasik, Magnus K Karlsson, Douglas P Kiel, Yongmei Liu, Osten Ljunggren, Mattias Lorentzon, Leo-Pekka Lyytikäinen, Thomas Meitinger, Dan Mellström, David Melzer, Iva Miljkovic, Matthias Nauck, Maria Nilsson, Brenda Penninx, Stephen R Pye, Ramachandran S Vasan, Martin Reincke, Fernando Rivadeneira, Abdelouahid Tajar, Alexander Teumer, André G Uitterlinden, Jagadish Ulloor, Jorma Viikari, Uwe Völker, Henry Völzke, H Erich Wichmann, Tsung-Sheng Wu, Wei Vivian Zhuang, Elad Ziv, Frederick C W Wu, Olli Raitakari, Anna Eriksson, Martin Bidlingmaier, Tamara B Harris, Anna Murray, Frank H de Jong, Joanne M Murabito, Shalender Bhasin, Liesbeth Vandenput, Robin Haring   +59 more
doaj   +1 more source

Low Testosterone and Sperm Quality Alterations: A Prospective Study of Sperm DNA Fragmentation and Chromatin Condensation in Infertile Men

Biology
(1) Background: Testosterone plays a key role in spermatogenesis and in maintaining semen quality and sperm DNA integrity. Consequently, reduced testosterone levels may disrupt these processes and contribute to male infertility.
Asmaa Serbouti, Kenza Berrada, Samy Housbane, Noureddine Louanjli, Rachid Aboutaieb   +4 more
doaj   +1 more source

Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Cancer Cells

International Journal of Endocrinology, 2016
Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action.
Huika Li, Thy Pham, Brett C. McWhinney, Jacobus P. Ungerer, Carel J. Pretorius, Derek J. Richard, Robin H. Mortimer, Michael C. d’Emden, Kerry Richard   +8 more
doaj   +1 more source