Results 51 to 60 of about 231,442 (307)

The enhancing effects of testosterone in exposure treatment for social anxiety disorder: a randomized proof-of-concept trial

Translational Psychiatry, 2021
Individuals with a social anxiety disorder (SAD) show hypofunctioning of the hypothalamus–pituitary-gonadal (HPG) axis, which is linked to social fear and avoidance behavior.
Moniek H. M. Hutschemaekers, Rianne A. de Kleine, Gert-Jan Hendriks, Mirjam Kampman, Karin Roelofs   +4 more
doaj   +1 more source

The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]

, 2012
Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core  

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Salivary testosterone levels in preadolescent children

BMC Pediatrics, 2002
Background Saliva reflects the plasma free fraction of testosterone which is biologically active, and available for uptake by tissues. Testosterone concentration in saliva, though differing slightly from the concentration of unbound testosterone in serum,
Dohnányiová Monika, Putz Zdenek, Pastor Karol, Ostatníková Daniela, Mat'ašeje Anna, Hampl Richard   +5 more
doaj   +1 more source

Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver

Frontiers in Endocrinology, 2023
Preclinical and clinical studies suggest that hypothyroidism might cause hepatic endocrine and metabolic disturbances with features that mimic deficiencies of testosterone and/or GH.
Leandro Fernández-Pérez, Leandro Fernández-Pérez, Borja Guerra, Borja Guerra, Carlota Recio, Juan José Cabrera-Galván, Irma García, Juan Vladimir De La Rosa, Antonio Castrillo, Antonio Castrillo, Antonio Castrillo, Diego Iglesias-Gato, Mario Díaz   +12 more
doaj   +1 more source

Testosterone Production and Competitive Factors

, 2023
Previous research demonstrates that testosterone facilitates psychological and physiological preparedness for competitive interactions while boosting the achievement motivation that drives one to compete.
Schock, Gabby
core  

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Sustained testosterone suppression: prognostic indicator in advanced hormone sensitive prostate cancer

Frontiers in Endocrinology
ObjectiveWe aimed to investigate the relationship between sustained testosterone suppression and clinical outcomes in advanced hormone-sensitive prostate cancer (aHSPC), which integrates longitudinal testosterone with castration duration to predict tumor
Dongsheng Ma, Dongsheng Ma, Tao Zhuo, Xin Huang, Jianhong Xi   +4 more
doaj   +1 more source

Testosterone-induced acute vascular responses.

, 2019
(A) Acute testosterone application resulted in increased vasoconstriction in the ACA of female rats subjected to combined VDD and hyperandrogenism (T♀D-) (*p = 0.015 and 0.016 vs. ♀D+ for 10−7 and 10−6 mol/L concentration, respectively; #p = 0.024 vs. ♀D-
Emil Monos (619618), Éva Pál (4825437), Eszter Horváth (3490238), Norbert Lippai (4825455), Attila Magyar (4825434), Szabolcs Várbíró (4825449), Zoltán Fontányi (4825440), Anna Monori-Kiss (619617), Eszter M. Horváth (6182036), Leila Hadjadj (4825443), György L. Nádasy (5660314), Zoltán Benyó (161876)   +11 more
core   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source