Results 51 to 60 of about 223,762 (305)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

An Overview of Testosterone Therapy

open access: yesAmerican Journal of Men's Health, 2016
Millions of men, as a result of the natural aging process, injury, illness, and medical therapies, experience a decline in testosterone levels that necessitate a need for testosterone supplementation therapy (TST).
O. Danny Lee PhD, APRN-BC, CNE   +1 more
doaj   +1 more source

Testosterone protects mice against zika virus infection and suppresses the inflammatory response in the brain

open access: yesiScience, 2022
Summary: Testosterone is essential to human growth and development as well as immune regulation. Zika virus (ZIKV), an emerging arbovirus associated with neurological complications including neuroinflammation, can also cause testicular damage and ...
Bohan Zheng   +8 more
doaj   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

open access: yesArthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci   +25 more
wiley   +1 more source

The enhancing effects of testosterone in exposure treatment for social anxiety disorder: a randomized proof-of-concept trial

open access: yesTranslational Psychiatry, 2021
Individuals with a social anxiety disorder (SAD) show hypofunctioning of the hypothalamus–pituitary-gonadal (HPG) axis, which is linked to social fear and avoidance behavior.
Moniek H. M. Hutschemaekers   +4 more
doaj   +1 more source

Asthma and Testosterone [PDF]

open access: yesNature, 1966
IT was previously shown1,2 that testosterone is a powerful inhibitor of histamine and SRS* responses, and in view of the varying age incidence of status asthmaticus in the two sexes it was thought testosterone levels might have aetiological significance. Dutch workers have thought along similar lines3. Accordingly blood levels were measured in male and
openaire   +2 more sources

The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]

open access: yes, 2012
Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core  

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

open access: yesAdvanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans   +7 more
wiley   +1 more source

Testosterone increases the virulence traits of uropathogenic Escherichia coli

open access: yesFrontiers in Microbiology
Uropathogenic Escherichia coli (UPEC) is the most common cause of urinary tract infections (UTIs) in humans. Testosterone negatively impacts UTIs by affecting the immune response, leading to higher susceptibility of chronic cystitis in individuals with ...
Rongrong Wu   +3 more
doaj   +1 more source

Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver

open access: yesFrontiers in Endocrinology, 2023
Preclinical and clinical studies suggest that hypothyroidism might cause hepatic endocrine and metabolic disturbances with features that mimic deficiencies of testosterone and/or GH.
Leandro Fernández-Pérez   +12 more
doaj   +1 more source

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