Results 151 to 160 of about 4,606 (238)

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Acute Stress Impacts Executive‐Social Function: Evidence From Prefrontal Activation and fNIRS‐Based Hyperscanning

Brain and Behavior, Volume 16, Issue 1, January 2026.
Trends in increased PFC activation and increased IBS may be indicative of compensatory neural mechanisms preserving performance under stress. Cognitive flexibility correlated with cooperative outcomes, tentatively supporting a neurobehavioral executive‐social link during acute stress inviting more research.
Zhihua Guo, Yue Gong, Liu Yang, Yushan Li, Rui Qiu, Xia Zhu   +5 more
wiley   +1 more source

Multidimensional Assessment of Neurological Adverse Reactions Related to PD‐1 Inhibitors: A Real‐World Pharmacovigilance Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This pharmacovigilance study systematically analyzed PD‐1 inhibitor–associated neurological adverse events using FAERS data from 2014 to 2024. Central nervous system toxicities, including encephalitis and brainstem encephalitis, were most prominent. Older age, female sex, specific cancer types, and combination therapies increased the risk, with most ...
Xiaofeng Hu, Xiaoli Wang, Bufu Tang, Dehuan Zhang, Rongbing Cai, Hui Jiang, Yaling Lin, Yiheng Song, Yiou Wang, Hairuo Huang, Dandan Guo, Xubin Sun, Hongjie Fan   +12 more
wiley   +1 more source

Depression Aggravates Immune‐Mediated Hepatitis Through NLRP3 Overactivation Induced by Intestinal Microbiota

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Depression is common in AIH patients and is associated with an elevated cirrhosis risk. AIH patients with depression, mice colonized with MDD microbiota, and ConA‐treated mice subjected to CUMS exhibit intestinal barrier dysfunction and hepatic NLRP3 inflammasome overactivation.
Simin Zhou, Liping Guo, Nian Chen, Haifeng Liu, Xin Liu, Jiwen Li, Shijing Dong, Jiangpeng Liu, Xiaoyi Wang, Ying Ran, Man Liu, Hongyu Chu, Yanni Li, Hui Yang, Jingwen Zhao, Lu Zhou   +15 more
wiley   +1 more source

Host Genetics and the Skin Microbiome Independently Predict Parasite Resistance

Ecology and Evolution, Volume 16, Issue 1, January 2026.
Host genetic selection and skin microbiome independently predict infection severity of ectoparasites. Furthermore, both factors together explain infection significantly better than either alone. ABSTRACT Host responses to parasite infection involve several interacting systems.
Rachael D. Kramp, Mary J. Janecka, Nadine Tardent, Jukka Jokela, Kevin D. Kohl, Jessica F. Stephenson   +5 more
wiley   +1 more source

Lipid‐Lowering Potential of Food Formulations Based on Culinary‐Treated Flours of Dioscorea bulbifera (Dana) in Obese and Hyperlipidemic Rats

Food Safety and Health, Volume 4, Issue 1, Page 233-246, January 2026.
This graphical abstract highlights the nutritional management of obesity through food formulations based on the two varieties (white and black) of Dioscorea bulbifera yams that has undergone culinary treatments (boiling and braising). The results show that white Dioscorea bulbifera showed the best properties compared to black after the culinary ...
Fossouo Towa Patrik Florent, Maffo Tazoho Ghislain, Tekou Florian Amel, Kenfack Justine Odelonne, Zokou Ronice, Dangang Bossi Donald Séverin, Womeni Hilaire Macaire   +6 more
wiley   +1 more source

Nobiletin Ameliorates Skeletal Muscle Performance in D‐Galactose‐Induced Aging Mice by Boosting Aerobic Metabolism

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Nob improved muscle function and prevented muscle atrophy in D‐gal‐induced aging mice. Nob enhanced the aerobic metabolism of myofibers in D‐gal‐induced aging mice. Nob activated the SIRT1/PGC1α/Nrf2 pathway, enhancing muscle metabolism and function. ABSTRACT The decrease in muscle performance during aging will not only lead to challenges in movement ...
Huihui Wang, Yangguang Zhang, Yijia Zhang, Xintong Wang, Yixuan Li, Fazheng Ren, Yanan Sun   +6 more
wiley   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Closer to the Heart: Cardiac Muscle Aerobic Capacity Correlates With Intraspecific Variation in Sprint Performance Rather Than Androgen Levels in the Neotropical Lizard Tropidurus catalanensis

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 1, Page 16-26, January 2026.
In male lizards Tropidurus catalanensis, sprint locomotor performance correlates with cardiac aerobic capacity. ABSTRACT Assessments of the interplay between physiology and whole‐organism performance are fundamental to understand how individuals function in different ecological contexts.
Willian Souza Lima, Danilo Giacometti, Paul J. Schaeffer, José Eduardo de Carvalho   +3 more
wiley   +1 more source