Transdermal delivery of testosterone [PDF]
, 2015 Male hypogonadism has been treated with exogenous testosterone since the 1930s. The early transdermal patches of testosterone became available in the 1980s with gel and solution preparations following subsequent decades.
Hadgraft, J, Lane, ME
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Nitric oxide modulates ATP-evoked currents in mouse Leydig cells
Brazilian Journal of Medical and Biological Research, 2018 Testosterone synthesis within Leydig cells is a calcium-dependent process. Intracellular calcium levels are regulated by different processes including ATP-activated P2X purinergic receptors, T-type Ca2+ channels modulated by the luteinizing hormone, and ...
J.L. de Deus +2 more
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Advances in hormone replacement therapy: making the menopause manageable
BMC Women's Health, 2008 The importance of the results of some large, randomized controlled trials (RCTs) on Hormone Replacement Therapy (HRT) has modified the risk/benefit perception of HRT. Recent literature review supports a different management.
Palacios Santiago
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Frontiers in Molecular Neuroscience, 2020 The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds 1-9) to influence the functional activity of inhibitory glycine and γ-aminobutyric acid (GABA) receptors was estimated.
Julia V. Bukanova +2 more
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Synaptic long-term potentiation and depression in the rat medial vestibular nuclei depend on neural activation of estrogenic and androgenic signals. [PDF]
PLoS ONE, 2013 Estrogenic and androgenic steroids can be synthesised in the brain and rapidly modulate synaptic transmission and plasticity through direct interaction with membrane receptors for estrogens (ERs) and androgens (ARs).
Mariangela Scarduzio +3 more
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Depigmented wing patch size is a condition-dependent indicator of viability in male collared flycatchers [PDF]
, 2003 Honesty of sexual advertisement is thought to be the result of signalling costs. Because production costs of depigmented plumage patches are probably very low, their role as honest signals of individual quality has been questioned. Costs of bearing these
Garamszegi, László Zsolt +2 more
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Male, Female, Other: Transgender and the Impact in Primary Care [PDF]
, 2016 Transgender includes patients at various stages of their journey. It is important that providers care for transgender patients with a culturally sensitive approach, awareness, and competent skill. There are new terms to learn.
Markwick, Laura
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A randomised comparison evaluating changes in bone mineral density in advanced prostate cancer: luteinising hormone-releasing hormone agonists versus transdermal oestradiol. [PDF]
, 2015 BACKGROUND: Luteinising hormone-releasing hormone agonists (LHRHa), used as androgen deprivation therapy (ADT) in prostate cancer (PCa) management, reduce serum oestradiol as well as testosterone, causing bone mineral density (BMD) loss.
Abel, PD +15 more
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Sex-specific phenotypic integration: Endocrine profiles, coloration, and behavior in fledgling boobies [PDF]
, 2015 The intensity of color expression in animals plays a key role in social environments as a mechanism to signal individual capacities in competitive contests. Selective pressures for resource competition differ at different stages of life and between sexes;
Fargallo, Juan A. +6 more
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A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]
, 1998 The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Beer +54 more
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